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Table 3 Multivariate associations between echocardiographic parameters and valvular or plasma AGEs and RAGE levels

From: Accumulation of advanced glycation end products (AGEs) is associated with the severity of aortic stenosis in patients with concomitant type 2 diabetes

Variable

AVA, estimate (95% CI)

p-value

Mean gradient, estimate (95% CI)

p-value

Maximum gradient, estimate (95% CI)

p-value

 Valvular AGEs, %

− 0.29 (− 0.10; − 0.47)

0.0035

0.24 (0.05; 0.43)

0.014

0.34 (0.15; 0.52)

0.0005

 Valvular RAGE, %

− 0.13 (− 0.32; 0.066)

0.19

0.082 (− 0.11; 0.28)

0.41

0.09 (− 0.11; 0.29)

0.36

 Plasma AGEs, ng/mL

− 0.20 (− 0.0041; − 0.39)

0.045

0.13 (− 0.069; 0.32)

0.20

0.04 (− 0.15; 0.24)

0.66

 Plasma sRAGE, pg/mL

− 0.26 (− 0.063; − 0.45)

0.01

0.13 (− 0.07; 0.33)

0.20

0.18 (− 0.16; 0.38)

0.071

 Valvular AGEs/sRAGE ratio

− 0.19 (0.007; − 0.39)

0.058

0.18 (− 0.02; 0.38)

0.078

0.19 (− 0.008; 0.39)

0.059

  1. All models were adjusted for age, hypertension, hypercholesterolemia, the use of statin, and angiotensin-converting enzyme inhibitors. CI confidence interval; for other abbreviations see Tables 1 and 2