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Table 3 Multivariate associations between echocardiographic parameters and valvular or plasma AGEs and RAGE levels

From: Accumulation of advanced glycation end products (AGEs) is associated with the severity of aortic stenosis in patients with concomitant type 2 diabetes

VariableAVA, estimate (95% CI)p-valueMean gradient, estimate (95% CI)p-valueMaximum gradient, estimate (95% CI)p-value
 Valvular AGEs, %− 0.29 (− 0.10; − 0.47)0.00350.24 (0.05; 0.43)0.0140.34 (0.15; 0.52)0.0005
 Valvular RAGE, %− 0.13 (− 0.32; 0.066)0.190.082 (− 0.11; 0.28)0.410.09 (− 0.11; 0.29)0.36
 Plasma AGEs, ng/mL− 0.20 (− 0.0041; − 0.39)0.0450.13 (− 0.069; 0.32)0.200.04 (− 0.15; 0.24)0.66
 Plasma sRAGE, pg/mL− 0.26 (− 0.063; − 0.45)0.010.13 (− 0.07; 0.33)0.200.18 (− 0.16; 0.38)0.071
 Valvular AGEs/sRAGE ratio− 0.19 (0.007; − 0.39)0.0580.18 (− 0.02; 0.38)0.0780.19 (− 0.008; 0.39)0.059
  1. All models were adjusted for age, hypertension, hypercholesterolemia, the use of statin, and angiotensin-converting enzyme inhibitors. CI confidence interval; for other abbreviations see Tables 1 and 2