Skip to main content

Table 2 Echocardiographic characteristics of the study population according to glucose metabolism status

From: Associations of (pre)diabetes with right ventricular and atrial structure and function: the Maastricht Study

Variable

NGM (n = 426)

Prediabetes (n = 142)

T2DM (n = 224)

Left atrium

 LA volume index, ml/m2

  Men

30.8 [26.6–34.9]

28.9 [25.0–34.7]

29.7 [25.2–34.5]

  Women

28.6 [24.7–33.3]

28.6 [25.3–33.2]

26.3 [23.2–32.4]

 LA volume, ml

  Men

62.0 [53.3–72.4]

62.3 [50.9–72.9]

61.1 [52.4–72.0]

  Women

50.9 [43.6–59.2]

52.9 [43.6–59.2]

51.3 [42.3–59.6]

Left ventricle, structure

 LV end diastolic volume index, ml/m2

  Men

68.5 ± 12.5

65.9 ± 11.8

63.0 ± 12.3‡

  Women

59.1 ± 10.6

58.1 ± 11.3

57.6 ± 11.9

 LV end systolic volume index, ml/m2

  Men

27.5 ± 6.1

26.7 ± 6.2

25.9 ± 6.3†

  Women

23.2 ± 4.6

23.0 ± 5.0

22.8 ± 5.3

 LV mass index, gr/m2.7

  Men

29.5 [25.3–35.1]

31.5 [27.4–35.0]

32.8 [27.0–37.5]‡

  Women

27.3 [24.0–31.3]

31.1 [25.5–36.7]‡

31.2 [27.1–34.7]‡

Left ventricular function

 Systolic LV function

  LV ejection fraction,  %

60.5 [58.8–62.4]

60.4 [58.8–62.0]

60.2 [57.8–61.7]‡

  TDI S’ septal (cm/s)a

7.5 ± 1.4

7.3 ± 1.3

7.4 ± 1.7

  TDI S’ lateral (cm/s)b

8.8 ± 2.0

8.8 ± 2.1

8.2 ± 2.0‡

 Diastolic LV function

  Early peak velocity (m/s)

0.68 ± 0.15

0.66 ± 0.14

0.68 ± 0.15

  Active peak velocity (m/s)c

0.66 ± 0.15

0.72 ± 0.17‡

0.75 ± 0.16‡

  E/A ratioc

1.03 [0.85–1.26]

0.89 [0.75–1.08]‡

0.89 [0.77–1.07]‡

  Deceleration time E-peak (msec)

191 ± 35

204 ± 38‡

202 ± 37‡

  Isovolumetric relaxation time (msec)d

94 ± 21

100 ± 24‡

94 ± 22

  S/D ratioe

1.38 ± 0.32

1.45 ± 0.36†

1.46 ± 0.31‡

  TDI E’ septal (cm/s)b

8.3

± 2.2

7.1

± 1.7‡

7.1

± 1.8‡

  TDI A’ septal (cm/s)f

9.8 ± 1.8

9.8 ± 1.7

10.0 ± 1.9

  TDI E’ lateral (cm/s)g

10.7 ± 2.7

9.5 ± 2.5‡

8.9 ± 2.2‡

  TDI A’ lateral (cm/s)h

10.6 ± 2.5

11.1 ± 2.4†

11.1 ± 2.3†

  E/E’-ratio averagedi

7.3 [6.2–8.7]

8.0 [6.9–9.7]‡

8.7 [7.6–10.1]‡

  Diastolic LV function (normal, indeterminate, abnormal, not specified), n (%)

175/183/42/26 (41.1/43.0/9.9/6.1)

30/79/23/10 (21.1/55.6/16.2/7.0)‡

44/115/40/25 (19.6/51.3/17.9/11.2)‡

Right atrium

 RA volume index, ml/m2

  Men

25.2 ± 7.2

22.1 ± 6.8‡

21.7 ± 6.2‡

  Women

21.3 ± 6.0

19.7 ± 5.5

18.3 ± 5.3‡

 RA volume, ml

  Men

48.1 [40.0–58.8]

43.4 [35.3–54.8]‡

43.7 [36.7–51.9]‡

  Women

36.0 29.7–45.1

36.0 [28.6–40.7]

33.7 [28.0–40.2]†

Right ventricle, structure

 RV diameter

  Men

41.3 ± 5.2

39.9 ± 5.3†

39.8 ± 4.7‡

  Women

35.6 ± 4.7

35.8 ± 5.6

35.0 ± 4.2

 RV length

  Men

75.8 ± 7.5

75.8 ± 7.0

75.9 ± 7.2

  Women

69.8 ± 6.6

70.3 ± 6.2

70.2 ± 7.3

Right ventricular function

 Systolic RV function

  S’ RV (cm/s)j

12.8 ± 2.4

12.4 ± 2.2

12.4 ± 2.5

  TAPSE (mm)k

23.0 ± 2.9

22.0 ± 3.6

22.3 ± 4.4

 Diastolic RV function

  E-peak velocity tricuspid flow (m/s)l

0.46 ± 0.09

0.44 ± 0.09

0.44 ± 0.08

  A-peak velocity tricuspid flow (m/s)m

0.35 ± 0.10

0.41 ± 0.07†

0.41 ± 0.09‡

  E/A ratio tricuspid valvem

1.30 [1.12–1.58]

1.10 [0.91–1.22]‡

1.10 [0.90–1.26]‡

  TDI E’ RV (cm/s)n

11.9 ± 2.7

10.4 ± 2.7‡

10.5 ± 2.7‡

  TDI A’ RV (cm/s)o

14.6 ± 3.5

13.9 ± 3.1†

14.1 ± 3.4

  E/E′-ratiok

4.3 [3.6–5.0]

4.8 [4.1–5.7]

4.6 [3.4–5.9]

 Global RV function

  Myocardial performance index RVp

0.47 ± 0.12

0.47 ± 0.12

0.48 ± 0.11

  Maximum tricuspid gradient

15.8 ± 6.2

14.7 ± 7.6

14.9 ± 7.2

Wall motion abnormalities, n yes (%)q

2 (0.5)

2 (1.4)

5 (2.3)†

Valvular dysfunction (moderate or severe), n (%)

28 (6.6)

8 (5.6)

13 (5.8)

  1. Data are presented as n (%), mean ± standard deviation or median (interquartile range)
  2. LA left atrial, LV left ventricular, TDI tissue Doppler imaging, RA right atrial, tricuspid annular plane systolic excursion, RV right ventricular
  3. Numbers of missing data (if n > 10); a n = 62; b n = 63; c n = 14; d n = 26; e n = 22; f n = 72; g n = 64; h n = 73; i n = 67; j n = 70; k n = 645; l n = 644; m n = 647; n n = 71; o n = 80; p n = 74; q n = 15
  4. P value difference prediabetes or T2DM vs NGM: * < 0.10, † < 0.05, ‡ < 0.01