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Table 2 Blood biochemistry before and after linagliptin treatment

From: Linagliptin, when compared to placebo, improves CD34+ve endothelial progenitor cells in type 2 diabetes subjects with chronic kidney disease taking metformin and/or insulin: a randomized controlled trial

 

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P value

Glucose

0.47

 Placebo

129.88 ± 43.78

129.35 ± 41.39

129.65 ± 46.78

 

 Linagliptin

124.71 ± 25.94

116.15 ± 23.16

109.92 ± 16.81

 

BUN

0.07

 Placebo

16.00 ± 5.56

17.41 ± 5.98

16.76 ± 5.85

 

 Linagliptin

18.07 ± 7.33

16.08 ± 6.10

16.85 ± 6.41

 

Serum creatinine

0.59

 Placebo

0.93 ± 0.27

0.91 ± 0.24

0.92 ± 0.25

 

 Linagliptin

1.06 ± 0.35

1.08 ± 0.43

1.1 ± 0.38

 

eGFR

0.78

 Placebo

84.06 ± 19.41

85.88 ± 19.41

84.12 ± 19.81

 

 Linagliptin

82.71 ± 20.96

82.85 ± 22.38

79.46 ± 19.9

 

Cholesterol

0.14

 Placebo

168.12 ± 53.16

173.29 ± 40.41

171.65 ± 48.49

 

 Linagliptin

166.29 ± 51.63

154.46 ± 37.32

159.69 ± 48.53

 

Triglycerides

0.13

 Placebo

118 ± 81.86

143.47 ± 126.7

127.76 ± 79.04

 

 Linagliptin

133.43 ± 67.97

130 ± 58.64

124.31 ± 50.67

 

LDL/HDL

0.04

 Placebo

1.76 ± 1.00

1.82 ± 0.83

1.76 ± 0.89

 

 Linagliptin

1.83 ± 0.78

1.65 ± 0.7

1.92 ± 0.87

 

HbA1c

0.12

 Placebo

7.35 ± 0.97

7.10 ± 0.79

7.27 ± 0.73

 

 Linagliptin

7.14 ± 0.67

6.76 ± 0.44

6.66 ± 0.40

 

C-reactive protein

0.49

 Placebo

4.50 ± 9.73

2.77 ± 2.51

3.08 ± 3.41

 

 Linagliptin

13.53 ± 31.32

8.4 ± 16.03

5.17 ± 6.54

 

IL6

0.18

 Placebo

5.16 ± 10.71

2.72 ± 3.01

2.18 ± 1.45

 

 Linagliptin

6.42 ± 11.00

5.24 ± 7.39

5.09 ± 6.08

 

TNFα

0.71

 Placebo

4.01 ± 10.42

5.94 ± 12.13

1.77 ± 1.94

 

 Linagliptin

4.10 ± 7.4

2.25 ± 2.57

1.92 ± 1.52

 

Leptin

0.43

 Placebo

22.48 ± 12.6

54.08 ± 130.71

22.88 ± 13.25

 

 Linagliptin

21.69 ± 22.77

23.06 ± 25.72

23.91 ± 25.83

 

Adiponectin

0.98

 Placebo

6.57 ± 5.04

6.5 ± 6.59

6.64 ± 6.33

 

 Linagliptin

5.39 ± 3.08

5.52 ± 2.98

5.45 ± 3.28

 

Insulin

0.87

 Placebo

17.85 ± 14.07

19.84 ± 11.83

20.82 ± 12.6

 

 Linagliptin

16.43 ± 12.9

16.06 ± 8.51

20.52 ± 19.71

 

Uric acid

0.97

 Placebo

6.51 ± 1.57

6.59 ± 1.21

6.73 ± 1.43

 

 Linagliptin

5.89 ± 1.78

5.96 ± 1.49

12.52 ± 21.85