Skip to main content

Table 2 Blood biochemistry before and after linagliptin treatment

From: Linagliptin, when compared to placebo, improves CD34+ve endothelial progenitor cells in type 2 diabetes subjects with chronic kidney disease taking metformin and/or insulin: a randomized controlled trial

  Visit 1 Visit 2 Visit 3 P value
Glucose 0.47
 Placebo 129.88 ± 43.78 129.35 ± 41.39 129.65 ± 46.78  
 Linagliptin 124.71 ± 25.94 116.15 ± 23.16 109.92 ± 16.81  
BUN 0.07
 Placebo 16.00 ± 5.56 17.41 ± 5.98 16.76 ± 5.85  
 Linagliptin 18.07 ± 7.33 16.08 ± 6.10 16.85 ± 6.41  
Serum creatinine 0.59
 Placebo 0.93 ± 0.27 0.91 ± 0.24 0.92 ± 0.25  
 Linagliptin 1.06 ± 0.35 1.08 ± 0.43 1.1 ± 0.38  
eGFR 0.78
 Placebo 84.06 ± 19.41 85.88 ± 19.41 84.12 ± 19.81  
 Linagliptin 82.71 ± 20.96 82.85 ± 22.38 79.46 ± 19.9  
Cholesterol 0.14
 Placebo 168.12 ± 53.16 173.29 ± 40.41 171.65 ± 48.49  
 Linagliptin 166.29 ± 51.63 154.46 ± 37.32 159.69 ± 48.53  
Triglycerides 0.13
 Placebo 118 ± 81.86 143.47 ± 126.7 127.76 ± 79.04  
 Linagliptin 133.43 ± 67.97 130 ± 58.64 124.31 ± 50.67  
LDL/HDL 0.04
 Placebo 1.76 ± 1.00 1.82 ± 0.83 1.76 ± 0.89  
 Linagliptin 1.83 ± 0.78 1.65 ± 0.7 1.92 ± 0.87  
HbA1c 0.12
 Placebo 7.35 ± 0.97 7.10 ± 0.79 7.27 ± 0.73  
 Linagliptin 7.14 ± 0.67 6.76 ± 0.44 6.66 ± 0.40  
C-reactive protein 0.49
 Placebo 4.50 ± 9.73 2.77 ± 2.51 3.08 ± 3.41  
 Linagliptin 13.53 ± 31.32 8.4 ± 16.03 5.17 ± 6.54  
IL6 0.18
 Placebo 5.16 ± 10.71 2.72 ± 3.01 2.18 ± 1.45  
 Linagliptin 6.42 ± 11.00 5.24 ± 7.39 5.09 ± 6.08  
TNFα 0.71
 Placebo 4.01 ± 10.42 5.94 ± 12.13 1.77 ± 1.94  
 Linagliptin 4.10 ± 7.4 2.25 ± 2.57 1.92 ± 1.52  
Leptin 0.43
 Placebo 22.48 ± 12.6 54.08 ± 130.71 22.88 ± 13.25  
 Linagliptin 21.69 ± 22.77 23.06 ± 25.72 23.91 ± 25.83  
Adiponectin 0.98
 Placebo 6.57 ± 5.04 6.5 ± 6.59 6.64 ± 6.33  
 Linagliptin 5.39 ± 3.08 5.52 ± 2.98 5.45 ± 3.28  
Insulin 0.87
 Placebo 17.85 ± 14.07 19.84 ± 11.83 20.82 ± 12.6  
 Linagliptin 16.43 ± 12.9 16.06 ± 8.51 20.52 ± 19.71  
Uric acid 0.97
 Placebo 6.51 ± 1.57 6.59 ± 1.21 6.73 ± 1.43  
 Linagliptin 5.89 ± 1.78 5.96 ± 1.49 12.52 ± 21.85