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Fig. 2 | Cardiovascular Diabetology

Fig. 2

From: Linagliptin, when compared to placebo, improves CD34+ve endothelial progenitor cells in type 2 diabetes subjects with chronic kidney disease taking metformin and/or insulin: a randomized controlled trial

Fig. 2

Gene expression of endothelial markers and antioxidant increased significantly. a Endothelial markers PECAM1, VEGF-A and vWF gene expression on CD34 negative cells from both placebo and Linagliptin Visit 3 patients. vWF mRNA expression is predominantly increased in at Visit-3 in Linagliptin group. Gene expression is normalized with to 18S and values are related to Visit-1. b Gene expression of antioxidant markers such as Catalase(CAT), Superoxide dismutase-2 or MnSOD (SOD2) and glutathione peroxidase (GPX3) gene expression on CD34 negative cells from both placebo and Linagliptin Visit 3 patients, shown here. mRNA expressions of these genes are increased in at Visit-3 in the Linagliptin group. Gene expression is normalized to 18S and gene expression values are fold difference to visit-1 values

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