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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: Autophagy-dependent and -independent modulation of oxidative and organellar stress in the diabetic heart by glucose-lowering drugs

Fig. 3

Mechanisms underlying the effects of glucose-lowering drugs to influence the development of cardiomyopathy. The possibility that glycosuria produced by SGLT2 inhibitors can promote renal urate excretion is not shown. AMPK: adenosine monophosphate-activated protein kinase; PGC-1α: peroxisome proliferator-activated receptor-γ coactivator-1α; SIRT1: sirtuin-1

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