High triglyceride-glucose index is associated with subclinical cerebral small vessel disease in a healthy population: a cross-sectional study

Table 5 Univariate linear regression analysis between triglyceride-glucose index (TyG) index and risk factors

	β (95% CI)	P-value
Age, years	0.001 (− 0.001 to 0.004)	0.333
Sex, male	0.224 (0.181 to 0.266)	< 0.001
Body mass index, kg/m²	0.058 (0.051 to 0.064)	< 0.001
Use of antihypertensives	0.134 (0.077 to 0.190)	< 0.001
Use of antiplatelet agents	0.064 (− 0.016 to 0.143)	0.119
Systolic blood pressure, mmHg	0.009 (0.007 to 0.010)	< 0.001
Diastolic blood pressure, mmHg	0.012 (0.010 to 0.014)	< 0.001
Hemoglobin A1c, %^*	2.004 (1.799 to 2.208)	< 0.001
Fasting glucose, mg/dL^*	1.833 (1.727 to 1.939)	< 0.001
Insulin, µU/mL^*	0.358 (0.324 to 0.391)	< 0.001
HOMA-IR^*	0.396 (0.367 to 0.426)	< 0.001
Total cholesterol, mg/dL	0.003 (0.002 to 0.003)	< 0.001
LDL cholesterol, mg/dL	0.001 (0.000 to 0.002)	0.020
HDL cholesterol, mg/dL	− 0.017 (− 0.019 to − 0.016)	< 0.001
Triglyceride, mg/dL^*	1.100 (1.087 to 1.112)	< 0.001
White blood cell counts, × 10³/μL	0.095 (0.083 to 0.108)	< 0.001
hs-CRP, mg/dL^*	0.047 (0.032 to 0.061)	< 0.001

HOMA-IR: Homeostatic Model Assessment for Insulin Resistance; LDL: low-density lipoprotein; HDL: high-density lipoprotein; hs-CRP: high-sensitivity C-reactive protein
^*These variables were transformed into a log scale

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