Table 1 Baseline cardiac characteristics of Sham and HF rats

Body weight: BW (g)

356 ± 6

370 ± 7

Heart weight: HW (g)

1.2 ± 0.1

1.6 ± 0.1*

HW/BW * 1000

3.2 ± 0.1

4.3 ± 0.2*

Infarct size (% of endocardial LV)

0

39 ± 2*

LVEDP (mmHg)

3 ± 1

21 ± 3*

LVESP (mmHg)

119 ± 4

106 ± 3

Heart rate (bpm)

350 ± 14

361 ± 14

+dP/dt (mmHg/s)

7161 ± 584

4783 ± 281*

−dP/dt (mmHg/s)

− 6878 ± 552

− 3745 ± 172*

LVEDD (mm)

8.0 ± 0.2

10.4 ± 0.2*

LVESD (mm)

4.8 ± 0.1

8.5 ± 0.2*

Fractional shortening (%)

39 ± 1

18 ± 1*

Ejection fraction (%)

64 ± 1

33 ± 1*

LVEDV (μl)

428 ± 27

653 ± 45*

LVESV (μl)

151 ± 14

443 ± 39*

Stroke volume (μl)

277 ± 14

209 ± 10*

Cardiac output (μl/min)

105 ± 2

66 ± 3*