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Table 1 Baseline cardiac characteristics of Sham and HF rats

From: GLP-1 mediated diuresis and natriuresis are blunted in heart failure and restored by selective afferent renal denervation

  Sham
(n = 10)
HF
(n = 10)
Body weight: BW (g) 356 ± 6 370 ± 7
Heart weight: HW (g) 1.2 ± 0.1 1.6 ± 0.1*
HW/BW * 1000 3.2 ± 0.1 4.3 ± 0.2*
Infarct size (% of endocardial LV) 0 39 ± 2*
LVEDP (mmHg) 3 ± 1 21 ± 3*
LVESP (mmHg) 119 ± 4 106 ± 3
Heart rate (bpm) 350 ± 14 361 ± 14
+dP/dt (mmHg/s) 7161 ± 584 4783 ± 281*
−dP/dt (mmHg/s) − 6878 ± 552 − 3745 ± 172*
LVEDD (mm) 8.0 ± 0.2 10.4 ± 0.2*
LVESD (mm) 4.8 ± 0.1 8.5 ± 0.2*
Fractional shortening (%) 39 ± 1 18 ± 1*
Ejection fraction (%) 64 ± 1 33 ± 1*
LVEDV (μl) 428 ± 27 653 ± 45*
LVESV (μl) 151 ± 14 443 ± 39*
Stroke volume (μl) 277 ± 14 209 ± 10*
Cardiac output (μl/min) 105 ± 2 66 ± 3*
  1. Values are mean ± SEM; n = 10 for each group of rats. LVEDP, left ventricular end-diastolic pressure
  2. LVESP left ventricular end-systolic pressure, +dP/dt maximal slope of systolic pressure increment. −dP/dt maximal slope of diastolic pressure decrement, LVEDD left ventricular end-diastolic dimension, LVESD left ventricular end-systolic dimension, LVEDV left ventricular end-diastolic volume, LVESD left ventricular end-systolic volume
  3. *P < 0.05 compared to Sham