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Table 1 Baseline cardiac characteristics of Sham and HF rats

From: GLP-1 mediated diuresis and natriuresis are blunted in heart failure and restored by selective afferent renal denervation

 Sham
(n = 10)
HF
(n = 10)
Body weight: BW (g)356 ± 6370 ± 7
Heart weight: HW (g)1.2 ± 0.11.6 ± 0.1*
HW/BW * 10003.2 ± 0.14.3 ± 0.2*
Infarct size (% of endocardial LV)039 ± 2*
LVEDP (mmHg)3 ± 121 ± 3*
LVESP (mmHg)119 ± 4106 ± 3
Heart rate (bpm)350 ± 14361 ± 14
+dP/dt (mmHg/s)7161 ± 5844783 ± 281*
−dP/dt (mmHg/s)− 6878 ± 552− 3745 ± 172*
LVEDD (mm)8.0 ± 0.210.4 ± 0.2*
LVESD (mm)4.8 ± 0.18.5 ± 0.2*
Fractional shortening (%)39 ± 118 ± 1*
Ejection fraction (%)64 ± 133 ± 1*
LVEDV (μl)428 ± 27653 ± 45*
LVESV (μl)151 ± 14443 ± 39*
Stroke volume (μl)277 ± 14209 ± 10*
Cardiac output (μl/min)105 ± 266 ± 3*
  1. Values are mean ± SEM; n = 10 for each group of rats. LVEDP, left ventricular end-diastolic pressure
  2. LVESP left ventricular end-systolic pressure, +dP/dt maximal slope of systolic pressure increment. −dP/dt maximal slope of diastolic pressure decrement, LVEDD left ventricular end-diastolic dimension, LVESD left ventricular end-systolic dimension, LVEDV left ventricular end-diastolic volume, LVESD left ventricular end-systolic volume
  3. *P < 0.05 compared to Sham