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Table 5 Components of the ROCK pathway in PBMCs (Western blot)

From: Rho kinase cascade activation in circulating leukocytes in patients with diabetes mellitus type 2

 

Control subjects

T2D patients

p

p38-MAPK P/T

1.00 ± 0.90

5.81 ± 3.50

0.001

p65-NFkB (UOD)

1.00 ± 0.45

1.34 ± 1.18

0.240

JAK2 P/T

1.00 ± 0.68

2.28 ± 2.10

0.052

ROCK2 (UOD)

1.00 ± 0.57

0.68 ± 0.65

0.080

JNK P/T

1.00 ± 0.63

0.90 ± 1.16

0.960

IL-6 (UOD)

1.00 ± 1.00

1.03 ± 0.75

0.920

MLC-2 P/T

1.00 ± 0.63

0.98 ± 1.16

0.960

  1. Values are shown as mean ± SD (fold vs control subjects) n = 22-27 Controls and 13 -18 T2D patients
  2. p38-MAPK p38 mitogen-activated protein kinase, p65-NFkB Nuclear factor NF-kappa-B p65 subunit, JAK2 Janus kinase 2, ROCK2 Rho kinase isoform 2, JNK Jun amino-terminal kinase, IL-6 interleukin 6, MLC-2 myosin light chain 2, P/T phosphorylated/total, UOD units of optical density
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Cardiovascular Diabetology

ISSN: 1475-2840