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Table 2 Risk of cardiovascular events (non-fatal myocardial infarction, ischemic stroke, and cardiovascular mortality) according to baseline fatty liver index quartiles

From: Fatty liver index and development of cardiovascular disease in Koreans without pre-existing myocardial infarction and ischemic stroke: a large population-based study

 EventsIncident rate (10,000 person-year)Unadjusted model HR(95% CI)Adjusted model HR (95% CI)
Model 1Model 2Model 3
Total (primary endpoint)
 FLI (Q1)487010.80RefRefRefRef
 FLI (Q2)911620.271.87 (1.81–1.94)1.35 (1.31–1.40)1.35 (1.30–1.40)1.31 (1.27–1.36)
 FLI (Q3)13,53530.162.78 (2.69–2.87)1.72 (1.66–1.78)1.71 (1.66–1.77)1.61 (1.55–1.66)
 FLI (Q4)18,48941.323.80 (3.69–3.93)2.28 (2.21–2.35)2.23 (2.16–2.30)1.99 (1.91–2.07)
 p for trend  < 0.0001< 0.0001< 0.0001< 0.0001
 Per one SD increase in FLI46,01025.601.45 (1.44–1.47)1.31 (1.30–1.32)1.29 (1.28–1.30)1.25 (1.23–1.27)
Myocardial infarction
 FLI (Q1)14713.27RefRefRefRef
 FLI (Q2)29496.582.01 (1.89–2.14)1.48 (1.39–1.58)1.47 (1.38–1.57)1.37 (1.29–1.46)
 FLI (Q3)491710.993.36 (3.17–3.57)2.10 (1.98–2.22)2.08 (1.96–2.21)1.79 (1.68–1.91)
 FLI (Q4)723716.244.97 (4.70–5.26)2.86 (2.70–3.03)2.78 (2.62–2.94)2.16 (2.01–2.31)
 p for trend  < 0.0001< 0.0001< 0.0001< 0.0001
 Per one SD increase in FLI16,5749.251.56 (1.54–1.58)1.38 (1.36–1.40)1.37 (1.34–1.38)1.24 (1.22–1.27)
Stroke
 FLI (Q1)25175.60RefRefRefRef
 FLI (Q2)467710.441.87 (1.78–1.96)1.33 (1.26–1.39)1.33 (1.26–1.39)1.33 (1.27–1.40)
 FLI (Q3)664514.862.66 (2.54–2.78)1.64 (1.56–1.71)1.63 (1.56–1.71)1.62 (1.54–1.70)
 FLI (Q4)844918.953.40 (3.25–3.55)2.10 (2.01–2.20)2.06 (1.96–2.15)2.01 (1.90–2.13)
 p for trend  < 0.0001< 0.0001< 0.0001< 0.0001
 Per one SD increase in FLI22,28812.451.39 (1.38–1.41)1.28 (1.26–1.29)1.26 (1.24–1.28)1.26 (1.23–1.28)
CV mortality
 FLI (Q1)8821.96RefRefRefRef
 FLI (Q2)14903.321.87 (1.80–1.93)1.35 (1.30–1.40)1.35 (1.30–1.39)1.31 (1.26–1.36)
 FLI (Q3)19734.402.77 (2.68–2.86)1.71 (1.66–1.77)1.71 (1.65–1.77)1.60 (1.54–1.66)
 FLI (Q4)28036.273.79 (3.67–3.91)2.27 (2.20–2.35)2.22 (2.15–2.29)1.98 (1.90–2.06)
 p for trend  < 0.0001< 0.0001< 0.0001< 0.0001
 Per one SD increase in FLI71483.981.43 (1.40–1.46)1.24 (1.21–1.27)1.22 (1.20–1.25)1.28 (1.24–1.32)
  1. Model 1: Adjusted for age and sex
  2. Model 2: Model 1 plus current smoking, regular exercise, and income
  3. Model 3: Model 2 plus body weight, total cholesterol, hypertension, diabetes, and use of medication for dyslipidemia
  4. HR hazard ratios, FLI fatty liver index, SD standard deviation