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Table 2 Risk of cardiovascular events (non-fatal myocardial infarction, ischemic stroke, and cardiovascular mortality) according to baseline fatty liver index quartiles

From: Fatty liver index and development of cardiovascular disease in Koreans without pre-existing myocardial infarction and ischemic stroke: a large population-based study

 

Events

Incident rate (10,000 person-year)

Unadjusted model HR(95% CI)

Adjusted model HR (95% CI)

Model 1

Model 2

Model 3

Total (primary endpoint)

 FLI (Q1)

4870

10.80

Ref

Ref

Ref

Ref

 FLI (Q2)

9116

20.27

1.87 (1.81–1.94)

1.35 (1.31–1.40)

1.35 (1.30–1.40)

1.31 (1.27–1.36)

 FLI (Q3)

13,535

30.16

2.78 (2.69–2.87)

1.72 (1.66–1.78)

1.71 (1.66–1.77)

1.61 (1.55–1.66)

 FLI (Q4)

18,489

41.32

3.80 (3.69–3.93)

2.28 (2.21–2.35)

2.23 (2.16–2.30)

1.99 (1.91–2.07)

 p for trend

  

< 0.0001

< 0.0001

< 0.0001

< 0.0001

 Per one SD increase in FLI

46,010

25.60

1.45 (1.44–1.47)

1.31 (1.30–1.32)

1.29 (1.28–1.30)

1.25 (1.23–1.27)

Myocardial infarction

 FLI (Q1)

1471

3.27

Ref

Ref

Ref

Ref

 FLI (Q2)

2949

6.58

2.01 (1.89–2.14)

1.48 (1.39–1.58)

1.47 (1.38–1.57)

1.37 (1.29–1.46)

 FLI (Q3)

4917

10.99

3.36 (3.17–3.57)

2.10 (1.98–2.22)

2.08 (1.96–2.21)

1.79 (1.68–1.91)

 FLI (Q4)

7237

16.24

4.97 (4.70–5.26)

2.86 (2.70–3.03)

2.78 (2.62–2.94)

2.16 (2.01–2.31)

 p for trend

  

< 0.0001

< 0.0001

< 0.0001

< 0.0001

 Per one SD increase in FLI

16,574

9.25

1.56 (1.54–1.58)

1.38 (1.36–1.40)

1.37 (1.34–1.38)

1.24 (1.22–1.27)

Stroke

 FLI (Q1)

2517

5.60

Ref

Ref

Ref

Ref

 FLI (Q2)

4677

10.44

1.87 (1.78–1.96)

1.33 (1.26–1.39)

1.33 (1.26–1.39)

1.33 (1.27–1.40)

 FLI (Q3)

6645

14.86

2.66 (2.54–2.78)

1.64 (1.56–1.71)

1.63 (1.56–1.71)

1.62 (1.54–1.70)

 FLI (Q4)

8449

18.95

3.40 (3.25–3.55)

2.10 (2.01–2.20)

2.06 (1.96–2.15)

2.01 (1.90–2.13)

 p for trend

  

< 0.0001

< 0.0001

< 0.0001

< 0.0001

 Per one SD increase in FLI

22,288

12.45

1.39 (1.38–1.41)

1.28 (1.26–1.29)

1.26 (1.24–1.28)

1.26 (1.23–1.28)

CV mortality

 FLI (Q1)

882

1.96

Ref

Ref

Ref

Ref

 FLI (Q2)

1490

3.32

1.87 (1.80–1.93)

1.35 (1.30–1.40)

1.35 (1.30–1.39)

1.31 (1.26–1.36)

 FLI (Q3)

1973

4.40

2.77 (2.68–2.86)

1.71 (1.66–1.77)

1.71 (1.65–1.77)

1.60 (1.54–1.66)

 FLI (Q4)

2803

6.27

3.79 (3.67–3.91)

2.27 (2.20–2.35)

2.22 (2.15–2.29)

1.98 (1.90–2.06)

 p for trend

  

< 0.0001

< 0.0001

< 0.0001

< 0.0001

 Per one SD increase in FLI

7148

3.98

1.43 (1.40–1.46)

1.24 (1.21–1.27)

1.22 (1.20–1.25)

1.28 (1.24–1.32)

  1. Model 1: Adjusted for age and sex
  2. Model 2: Model 1 plus current smoking, regular exercise, and income
  3. Model 3: Model 2 plus body weight, total cholesterol, hypertension, diabetes, and use of medication for dyslipidemia
  4. HR hazard ratios, FLI fatty liver index, SD standard deviation
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Cardiovascular Diabetology

ISSN: 1475-2840