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Table 3 Hazard ratios and 95% confidence intervals of all-cause mortality by 10 categories of fasting glucose level at baseline stratified by Charlson co-morbidity index (CCI)

From: The sweet spot: fasting glucose, cardiovascular disease, and mortality in older adults with diabetes: a nationwide population-based study

All-cause mortality

 

Fasting glucose (mg/dL)

Number of subjects

Number of event

Follow-up duration (person-years)

Incident rate (per 1000 person-years)

Crude hazard ratio (95% confidence interval)

Adjusted hazard ratioa (95% confidence interval)

P for interaction

CCI (≤ 2)

≤ 79

579

72

3316.07

21.71

1.6 (1.26–2.03)

1.33 (1.05–1.68)

0.12

80–94

4344

432

25,071.35

17.23

1.27 (1.14–1.41)

1.17 (1.06–1.31)

 

95–109

13,120

1148

76,002.87

15.10

1.11 (1.03–1.20)

1.09 (1.01–1.18)

 

110–124

19,268

1527

112,249.59

13.60

1 (reference)

1 (reference)

 

125–139

21,556

1808

125,243.71

14.44

1.06 (0.99–1.14)

1.04 (0.97–1.12)

 

140–154

13,930

1286

80,764.71

15.92

1.17 (1.09–1.26)

1.14 (1.06–1.23)

 

155–169

7284

752

42,089.97

17.87

1.32 (1.21–1.44)

1.25 (1.14–1.36)

 

170–184

4046

460

23,372.6

19.68

1.45 (1.31–1.61)

1.41 (1.27–1.56)

 

185–199

2349

336

13,361.23

25.15

1.86 (1.65–2.09)

1.71 (1.52–1.92)

 

≥ 200

3484

557

19,744.85

28.21

2.09 (1.90–2.30)

1.96 (1.77–2.16)

 

CCI (≥ 3)

≤ 79

1334

277

7321.85

37.83

1.86 (1.65–2.11)

1.59 (1.41–1.80)

 

80–94

8807

1425

49,350.22

28.88

1.41 (1.33–1.50)

1.28 (1.20–1.36)

 

95–109

23,801

3090

135,541.38

22.80

1.11 (1.06–1.17)

1.08 (1.03–1.14)

 

110–124

31,760

3733

181,750.05

20.54

1 (reference)

1 (reference)

 

125–139

28,913

3565

165,145.88

21.59

1.05 (1.00–1.10)

1.07 (1.02–1.12)

 

140–154

17,833

2385

101,409.37

23.52

1.15 (1.09–1.21)

1.15 (1.09–1.21)

 

155–169

10,097

1475

57,333.12

25.73

1.25 (1.18–1.33)

1.23 (1.16–1.31)

 

170–184

6021

956

33,959.21

28.15

1.37 (1.28–1.48)

1.32 (1.23–1.42)

 

185–199

3659

656

20,435.25

32.10

1.57 (1.45–1.71)

1.53 (1.40–1.66)

 

≥ 200

5753

1272

31,644.94

40.20

1.98 (1.85–2.11)

1.84 (1.73–1.97)

 
  1. aHazard ratios were calculated by Cox models after adjusting for age at baseline, sex, family income, residential area, smoking status, diabetes duration (≥ 5 years/< 5 year), alcohol intake, regular exercise, body mass index, systolic blood pressure, and total cholesterol