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Table 2 HRs (95% (CI) of CVD and CHD for subjects with incident IR and those with changing IR status between baseline and the first follow-up (n = 803)

From: Change in glucose intolerance status and risk of incident cardiovascular disease: Tehran Lipid and Glucose Study

 

Model 1a

Model 2b

Model 3c

HR 95% CI

P-value

HR 95% CI

P-value

HR 95% CI

P-value

Incident IR

      

 CVD

      

  IS in both visits

1.00

 

1.00

 

1.00

 

  IS to IR

1.02 (0.66–1.60)

0.91

0.85 (0.54–1.36)

0.50

0.80 (0.50–1.28)

0.35

 CHD

      

  IS in both visits

1.00

 

1.00

 

1.00

 

  IS to IR

1.08 (0.67–1.73)

0.76

0.93 (0.57–1.53)

0.79

0.90 (0.54–1.49)

0.67

Changing IR

 CVD

      

  IR in both visits

1.00

 

1.00

 

1.00

 

  IR to IS

1.07 (0.62–1.85)

0.80

1.25 (0.72–2.19)

0.42

1.40 (0.79–2.48)

0.25

  IR to diabetes

3.30 (1.40–7.80)

0.01

3.74 (1.55–9.03)

0.01

3.68 (1.49–9.06)

0.01

 CHD

      

  IR in both visits

1.00

 

1.00

 

1.00

 

  IR to IS

1.23 (0.69–2.18)

0.48

1.47 (0.82–2.64)

0.20

1.53 (0.84–2.78)

0.17

  IR to diabetes

2.73 (1.06–7.02)

0.04

3.21 (1.21–8.53)

0.01

2.76 (1.00–7.60)

0.05

  1. Incident IR, those who converted from IS state to IR state. IR and IS among men was defined as HOMA-IR ≥ 2.17 µU/mL and < 2.17 µU/mL, respectively; corresponding values form women were ≥ 1.85 µU/mL and < 1.85 µU/mL respectively [23]
  2. IR, insulin resistance; IS, insulin sensitive; HR, hazard ratios; CI, confidence interval; CVD, cardiovascular disease; CHD, coronary heart disease
  3. aModel 1: Age, sex
  4. bModel 2: Model 1 + systolic blood pressure, diastolic blood pressure, total cholesterol, high density lipoprotein-cholesterol, waist circumference, eGFR, physical activity, smoking, education and use of anti-hypertensive drugs
  5. cModel 3: Model 2 + change of waist circumference, total cholesterol and high density lipoprotein-cholesterol
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Cardiovascular Diabetology

ISSN: 1475-2840