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Fig. 4 | Cardiovascular Diabetology

Fig. 4

From: Sodium-glucose cotransporter 2 inhibitors antagonize lipotoxicity in human myeloid angiogenic cells and ADP-dependent activation in human platelets: potential relevance to prevention of cardiovascular events

Fig. 4

Flow-cytometry analysis of SGLT2i effects on platelet activation. Surface expressions of αIIbβ3 complex, recognized by PAC1 binding (a), and CD62p (b) were tested on resting platelets (R) and platelets activated with 5 µM ADP, alone (ADP) or in combination with Empagliflozin 1uM (ADP+ EMPA 1uM) or with Dapagliflozin 1uM (ADP+ DAPA 1uM), by flow cytometry. Data are expressed as mean of positive platelets (%) ± SEM from at least 3 independent experiments. #p < 0.05 vs R; *p < 0.05 vs ADP

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Cardiovascular Diabetology

ISSN: 1475-2840