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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: Sodium-glucose cotransporter 2 inhibitors antagonize lipotoxicity in human myeloid angiogenic cells and ADP-dependent activation in human platelets: potential relevance to prevention of cardiovascular events

Fig. 3

Effects of SGLT2i on pro-inflammatory cytokine/chemokine secretion in SA-treated MAC. Protein expression levels of TNF-α (a and b), IL-8 (c and d), MCP1 (e and f) and IL-1β (g and h) were assessed in MAC pre-treated with empagliflozin (Empa) or dapagliflozin (Dapa) 100 µM for 16 h followed by 3 h (a, c, e, g on the left) or 6 h (b, d, f, h on the right) of stearate (SA) 100 µM incubation (IL interleukin, TNFa tumor necrosis factor-α, MCP monocyte chemoattractant protein). Bars in the boxes represent the median (min to max values) of at least 4 independent experiments (*p < 0.05, **p < 0.01 vs SA)

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Cardiovascular Diabetology

ISSN: 1475-2840