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Table 4 Fibrinogen levels in relation to cardiovascular events in patients with different glucose metabolism status

From: Fibrinogen is associated with glucose metabolism and cardiovascular outcomes in patients with coronary artery disease

 

Events/subjects

HR (95% CI)

476/5237

Crude model

Adjusted model

NGR

 Low Fib

25/510

Reference

Reference

 Medium Fib

28/365

1.56 (0.91–2.67)

1.47 (0.85–2.52)

 High Fib

23/270

1.81 (1.03–3.18)*

1.56 (0.87–2.80)

Pre-DM

 Low Fib

55/791

1.36 (0.85–2.19)

1.24 (0.78–2.00)

 Medium Fib

72/814

1.81 (1.15–2.85)*

1.58 (0.99–2.51)

 High Fib

81/850

1.95 (1.25–3.05)*

1.61 (1.01–2.59) *

DM

 Low Fib

45/445

2.09 (1.28–3.41)*

1.81 (1.13–2.92) *

 Medium Fib

60/567

2.15 (1.35–3.43)*

1.86 (1.14–3.05) *

 High Fib

87/625

2.89 (1.85–4.50)*

2.28 (1.42–3.66) *

  1. Model adjusted for age, sex, body mass index, smoking, hypertension, family history of coronary artery disease, left ventricular ejection fraction, low density lipoprotein cholesterol, high lipoprotein cholesterol, Ln-transformed triglyceride, Ln-transformed high-sensitivity C-reactive protein, and creatinine. * p-value < 0.05. Fib fibrinogen, NGR normal glucose regulation, Pre-DM pre-diabetes mellitus, DM diabetes mellitus