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Table 1 Baseline characteristics of study population according to fibrinogen levels

From: Fibrinogen is associated with glucose metabolism and cardiovascular outcomes in patients with coronary artery disease

  Total
(n = 5237)
Low Fib
(< 2.82 mg/dL)
(n = 1746)
Medium Fib
(2.82–3.39 mg/dL)
(n = 1746)
High Fib
(> 3.39 mg/dL)
(n = 1745)
p-value for trend
Age, years 57.79 ± 10.11 56.23 ± 9.91 57.86 ± 9.97 59.28 ± 10.21 < 0.001
Male, n (%) 3729 (71.2) 1372 (78.6) 1241 (71.1) 1113 (63.8) < 0.001
BMI (kg/m2) 25.78 ± 3.17 25.65 ± 3.08 25.76 ± 3.02 25.92 ± 3.39 0.041
Hypertension, n (%) 3320 (63.4) 1047 (60.0) 1114 (63.8) 1158 (66.4) < 0.001
Diabetes, n (%) 1637 (31.3) 445 (25.5) 567 (32.5) 625 (35.8) < 0.001
Family history of CAD, n (%) 812 (15.5) 276 (15.8) 267 (15.3) 267 (15.3) 0.916
Current Smokers, n (%) 2807 (53.6) 981 (56.2) 946 (54.2) 879 (50.4) 0.002
Drinkers, n (%) 1628 (31.1) 597 (34.2) 529 (30.3) 502 (28.8) 0.002
FBG (mmol/L) 5.75 ± 1.72 5.52 ± 1.53 5.74 ± 1.68 5.98 ± 1.90 < 0.001
HbA1c (%) 6.33 ± 1.10 6.09 ± 0.92 6.35 ± 1.09 6.54 ± 1.23 < 0.001
Creatinine (μmol) 76.61 ± 18.68 15.92 ± 0.38 17.64 ± 0.42 21.96 ± 0.53 0.297
TC (mmol/L) 4.17 ± 1.16 4.00 ± 1.07 4.19 ± 1.14 4.31 ± 1.24 < 0.001
HDL-C (mmol/L) 1.05 ± 0.28 1.05 ± 0.28 1.04 ± 0.27 1.06 ± 0.30 0.463
LDL-C (mmol/L) 2.54 ± 1.00 2.41 ± 0.95 2.54 ± 0.95 2.66 ± 1.07 < 0.001
TG (mmol/L) 1.52 (1.13–2.12) 1.48 (1.06–2.04) 1.55 (1.14–2.20) 1.53 (1.17–2.87) 0.001
HsCRP, mg/dL 1.46 (0.73–2.98) 0.83 (0.49–1.39) 1.38 (0.75–2.43) 3.20 (1.65–7.58) < 0.001
LVEF (%) 64.56 ± 7.29 65.13 ± 6.94 64.86 ± 6.87 63.68 ± 7.95 < 0.001
Medications at discharge
 Statins, n (%) 5106 (97.5) 1707 (97.8) 1699 (97.3) 1699 (97.4) 0.538
 Aspirin, n (%) 5163 (98.6) 1716 (98.3) 1721 (98.6) 1724 (98.8) 0.524
 β-blockers,  % 4137 (79.0) 1365 (78.2) 1347 (77.2) 1422 (81.5) 0.004
 ACEI/ARB, % 2602 (49.7) 813 (46.6) 860 (49.3) 928 (53.2) < 0.001
 CCB, n (%) 2115 (40.4) 689 (39.5) 738 (42.3) 685 (39.3) 0.134
  1. The data are presented as mean ± standard deviation, median (interquartile range) or number (%). BMI body mass index, CAD coronary artery disease, HbA1c glycosylated hemoglobin, FBG fasting blood glucose, TC total cholesterol HDL-C high-density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol, TG triglyceride, HsCRP high-sensitivity C-reactive protein, LVEF left ventricular ejection fraction, ACEI angiotensin-converting enzyme inhibitors, ARB angiotensin receptor blockers, CCB calcium channel blockers