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Table 1 Baseline characteristics of study population according to fibrinogen levels

From: Fibrinogen is associated with glucose metabolism and cardiovascular outcomes in patients with coronary artery disease

 Total
(n = 5237)
Low Fib
(< 2.82 mg/dL)
(n = 1746)
Medium Fib
(2.82–3.39 mg/dL)
(n = 1746)
High Fib
(> 3.39 mg/dL)
(n = 1745)
p-value for trend
Age, years57.79 ± 10.1156.23 ± 9.9157.86 ± 9.9759.28 ± 10.21< 0.001
Male, n (%)3729 (71.2)1372 (78.6)1241 (71.1)1113 (63.8)< 0.001
BMI (kg/m2)25.78 ± 3.1725.65 ± 3.0825.76 ± 3.0225.92 ± 3.390.041
Hypertension, n (%)3320 (63.4)1047 (60.0)1114 (63.8)1158 (66.4)< 0.001
Diabetes, n (%)1637 (31.3)445 (25.5)567 (32.5)625 (35.8)< 0.001
Family history of CAD, n (%)812 (15.5)276 (15.8)267 (15.3)267 (15.3)0.916
Current Smokers, n (%)2807 (53.6)981 (56.2)946 (54.2)879 (50.4)0.002
Drinkers, n (%)1628 (31.1)597 (34.2)529 (30.3)502 (28.8)0.002
FBG (mmol/L)5.75 ± 1.725.52 ± 1.535.74 ± 1.685.98 ± 1.90< 0.001
HbA1c (%)6.33 ± 1.106.09 ± 0.926.35 ± 1.096.54 ± 1.23< 0.001
Creatinine (μmol)76.61 ± 18.6815.92 ± 0.3817.64 ± 0.4221.96 ± 0.530.297
TC (mmol/L)4.17 ± 1.164.00 ± 1.074.19 ± 1.144.31 ± 1.24< 0.001
HDL-C (mmol/L)1.05 ± 0.281.05 ± 0.281.04 ± 0.271.06 ± 0.300.463
LDL-C (mmol/L)2.54 ± 1.002.41 ± 0.952.54 ± 0.952.66 ± 1.07< 0.001
TG (mmol/L)1.52 (1.13–2.12)1.48 (1.06–2.04)1.55 (1.14–2.20)1.53 (1.17–2.87)0.001
HsCRP, mg/dL1.46 (0.73–2.98)0.83 (0.49–1.39)1.38 (0.75–2.43)3.20 (1.65–7.58)< 0.001
LVEF (%)64.56 ± 7.2965.13 ± 6.9464.86 ± 6.8763.68 ± 7.95< 0.001
Medications at discharge
 Statins, n (%)5106 (97.5)1707 (97.8)1699 (97.3)1699 (97.4)0.538
 Aspirin, n (%)5163 (98.6)1716 (98.3)1721 (98.6)1724 (98.8)0.524
 β-blockers,  %4137 (79.0)1365 (78.2)1347 (77.2)1422 (81.5)0.004
 ACEI/ARB, %2602 (49.7)813 (46.6)860 (49.3)928 (53.2)< 0.001
 CCB, n (%)2115 (40.4)689 (39.5)738 (42.3)685 (39.3)0.134
  1. The data are presented as mean ± standard deviation, median (interquartile range) or number (%). BMI body mass index, CAD coronary artery disease, HbA1c glycosylated hemoglobin, FBG fasting blood glucose, TC total cholesterol HDL-C high-density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol, TG triglyceride, HsCRP high-sensitivity C-reactive protein, LVEF left ventricular ejection fraction, ACEI angiotensin-converting enzyme inhibitors, ARB angiotensin receptor blockers, CCB calcium channel blockers