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Table 1 Baseline characteristics of study population according to fibrinogen levels

From: Fibrinogen is associated with glucose metabolism and cardiovascular outcomes in patients with coronary artery disease

 

Total

(n = 5237)

Low Fib

(< 2.82 mg/dL)

(n = 1746)

Medium Fib

(2.82–3.39 mg/dL)

(n = 1746)

High Fib

(> 3.39 mg/dL)

(n = 1745)

p-value for trend

Age, years

57.79 ± 10.11

56.23 ± 9.91

57.86 ± 9.97

59.28 ± 10.21

< 0.001

Male, n (%)

3729 (71.2)

1372 (78.6)

1241 (71.1)

1113 (63.8)

< 0.001

BMI (kg/m2)

25.78 ± 3.17

25.65 ± 3.08

25.76 ± 3.02

25.92 ± 3.39

0.041

Hypertension, n (%)

3320 (63.4)

1047 (60.0)

1114 (63.8)

1158 (66.4)

< 0.001

Diabetes, n (%)

1637 (31.3)

445 (25.5)

567 (32.5)

625 (35.8)

< 0.001

Family history of CAD, n (%)

812 (15.5)

276 (15.8)

267 (15.3)

267 (15.3)

0.916

Current Smokers, n (%)

2807 (53.6)

981 (56.2)

946 (54.2)

879 (50.4)

0.002

Drinkers, n (%)

1628 (31.1)

597 (34.2)

529 (30.3)

502 (28.8)

0.002

FBG (mmol/L)

5.75 ± 1.72

5.52 ± 1.53

5.74 ± 1.68

5.98 ± 1.90

< 0.001

HbA1c (%)

6.33 ± 1.10

6.09 ± 0.92

6.35 ± 1.09

6.54 ± 1.23

< 0.001

Creatinine (μmol)

76.61 ± 18.68

15.92 ± 0.38

17.64 ± 0.42

21.96 ± 0.53

0.297

TC (mmol/L)

4.17 ± 1.16

4.00 ± 1.07

4.19 ± 1.14

4.31 ± 1.24

< 0.001

HDL-C (mmol/L)

1.05 ± 0.28

1.05 ± 0.28

1.04 ± 0.27

1.06 ± 0.30

0.463

LDL-C (mmol/L)

2.54 ± 1.00

2.41 ± 0.95

2.54 ± 0.95

2.66 ± 1.07

< 0.001

TG (mmol/L)

1.52 (1.13–2.12)

1.48 (1.06–2.04)

1.55 (1.14–2.20)

1.53 (1.17–2.87)

0.001

HsCRP, mg/dL

1.46 (0.73–2.98)

0.83 (0.49–1.39)

1.38 (0.75–2.43)

3.20 (1.65–7.58)

< 0.001

LVEF (%)

64.56 ± 7.29

65.13 ± 6.94

64.86 ± 6.87

63.68 ± 7.95

< 0.001

Medications at discharge

 Statins, n (%)

5106 (97.5)

1707 (97.8)

1699 (97.3)

1699 (97.4)

0.538

 Aspirin, n (%)

5163 (98.6)

1716 (98.3)

1721 (98.6)

1724 (98.8)

0.524

 β-blockers,  %

4137 (79.0)

1365 (78.2)

1347 (77.2)

1422 (81.5)

0.004

 ACEI/ARB, %

2602 (49.7)

813 (46.6)

860 (49.3)

928 (53.2)

< 0.001

 CCB, n (%)

2115 (40.4)

689 (39.5)

738 (42.3)

685 (39.3)

0.134

  1. The data are presented as mean ± standard deviation, median (interquartile range) or number (%). BMI body mass index, CAD coronary artery disease, HbA1c glycosylated hemoglobin, FBG fasting blood glucose, TC total cholesterol HDL-C high-density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol, TG triglyceride, HsCRP high-sensitivity C-reactive protein, LVEF left ventricular ejection fraction, ACEI angiotensin-converting enzyme inhibitors, ARB angiotensin receptor blockers, CCB calcium channel blockers