Parameter | Group | 2-way ANOVA p value | |||||
---|---|---|---|---|---|---|---|
+/+ Veh | +/+ LIRA | fa/fa Veh | fa/fa LIRA | Genotype | Treatment | Interaction | |
HR (bpm) | 435 ± 28 | 452 ± 42 | 369 ± 22 | 375 ± 33 | < 0.0001 | 0.191 | 0.416 |
IVSd (mm) | 1.81 ± 0.14 | 1.87 ± 0.08 | 2.35 ± 0.10 | 2.42 ± 0.21 | 0.003 | 0.903 | 0.719 |
IVSs (mm) | 2.91 ± 0.11 | 3.09 ± 0.25 | 3.27 ± 0.13 | 3.08 ± 0.11 | 0.102 | 0.255 | 0.828 |
LVIDd (mm) | 6.17 ± 0.10 | 6.21 ± 0.23 | 6.76 ± 0.18 | 6.73 ± 0.26 | 0.033 | 0.953 | 0.941 |
LVIDs (mm) | 2.46 ± 0.26 | 2.55 ± 0.43 | 3.87 ± 0.41 | 3.42 ± 0.19 | 0.007 | 0.960 | 0.249 |
LVPWd (mm) | 2.37 ± 0.21 | 2.27 ± 0.25 | 2.63 ± 0.31 | 2.72 ± 0.20 | 0.059 | 0.800 | 0.912 |
LVPWs (mm) | 3.42 ± 0.15 | 3.58 ± 0.25 | 3.30 ± 0.15 | 3.33 ± 0.17 | 0.556 | 0.589 | 0.705 |
EF (%) | 90.63 ± 0.99 | 89.70 ± 1.39 | 82.96 ± 1.49* | 84.09 ± 2.15* | 0.0007 | 0.688 | 0.272 |
FS (%) | 63.53 ± 1.56 | 62.69 ± 2.22 | 53.49 ± 1.90* | 55.17 ± 2.50* | 0.0006 | 0.658 | 0.211 |
CO (mL/min) | 9.46 ± 0.41 | 10.53 ± 0.71 | 7.91 ± 0.93 | 9.22 ± 0.71 | 0.028 | 0.123 | 0.888 |