Skip to main content

Table 2 Echocardiographic parameters of Zucker rats after LIRA treatment on a high-salt diet

From: Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet

Parameter

Group

2-way ANOVA p value

+/+ Veh

+/+ LIRA

fa/fa Veh

fa/fa LIRA

Genotype

Treatment

Interaction

HR (bpm)

435 ± 28

452 ± 42

369 ± 22

375 ± 33

< 0.0001

0.191

0.416

IVSd (mm)

1.81 ± 0.14

1.87 ± 0.08

2.35 ± 0.10

2.42 ± 0.21

0.003

0.903

0.719

IVSs (mm)

2.91 ± 0.11

3.09 ± 0.25

3.27 ± 0.13

3.08 ± 0.11

0.102

0.255

0.828

LVIDd (mm)

6.17 ± 0.10

6.21 ± 0.23

6.76 ± 0.18

6.73 ± 0.26

0.033

0.953

0.941

LVIDs (mm)

2.46 ± 0.26

2.55 ± 0.43

3.87 ± 0.41

3.42 ± 0.19

0.007

0.960

0.249

LVPWd (mm)

2.37 ± 0.21

2.27 ± 0.25

2.63 ± 0.31

2.72 ± 0.20

0.059

0.800

0.912

LVPWs (mm)

3.42 ± 0.15

3.58 ± 0.25

3.30 ± 0.15

3.33 ± 0.17

0.556

0.589

0.705

EF (%)

90.63 ± 0.99

89.70 ± 1.39

82.96 ± 1.49*

84.09 ± 2.15*

0.0007

0.688

0.272

FS (%)

63.53 ± 1.56

62.69 ± 2.22

53.49 ± 1.90*

55.17 ± 2.50*

0.0006

0.658

0.211

CO (mL/min)

9.46 ± 0.41

10.53 ± 0.71

7.91 ± 0.93

9.22 ± 0.71

0.028

0.123

0.888

  1. HR heart rate, IVSd interventricular septal thickness at end-diastole, IVSs interventricular septal thickness at end-systole, LVIDd left ventricular (LV) internal dimension at end-diastole, LVIDs LV internal dimension at end-systole, LVPWd LV posterior wall thickness at end-diastole, LVPWs LV posterior wall thickness at end-systole, EF ejection fraction, FS fractional shortening, CO cardiac output. Age-matched +/+ Veh, lean rats treated with vehicle; +/+ LIRA, lean rats treated with LIRA (0.1 mg/kg/day); fa/fa Veh, obese rats treated with vehicle; fa/fa LIRA, obese rats treated with LIRA (0.1 mg/kg/day)
  2. *p < 0.05 vs lean rats