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Table 2 Echocardiographic parameters of Zucker rats after LIRA treatment on a high-salt diet

From: Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet

ParameterGroup2-way ANOVA p value
+/+ Veh+/+ LIRAfa/fa Vehfa/fa LIRAGenotypeTreatmentInteraction
HR (bpm)435 ± 28452 ± 42369 ± 22375 ± 33< 0.00010.1910.416
IVSd (mm)1.81 ± 0.141.87 ± 0.082.35 ± 0.102.42 ± 0.210.0030.9030.719
IVSs (mm)2.91 ± 0.113.09 ± 0.253.27 ± 0.133.08 ± 0.110.1020.2550.828
LVIDd (mm)6.17 ± 0.106.21 ± 0.236.76 ± 0.186.73 ± 0.260.0330.9530.941
LVIDs (mm)2.46 ± 0.262.55 ± 0.433.87 ± 0.413.42 ± 0.190.0070.9600.249
LVPWd (mm)2.37 ± 0.212.27 ± 0.252.63 ± 0.312.72 ± 0.200.0590.8000.912
LVPWs (mm)3.42 ± 0.153.58 ± 0.253.30 ± 0.153.33 ± 0.170.5560.5890.705
EF (%)90.63 ± 0.9989.70 ± 1.3982.96 ± 1.49*84.09 ± 2.15*0.00070.6880.272
FS (%)63.53 ± 1.5662.69 ± 2.2253.49 ± 1.90*55.17 ± 2.50*0.00060.6580.211
CO (mL/min)9.46 ± 0.4110.53 ± 0.717.91 ± 0.939.22 ± 0.710.0280.1230.888
  1. HR heart rate, IVSd interventricular septal thickness at end-diastole, IVSs interventricular septal thickness at end-systole, LVIDd left ventricular (LV) internal dimension at end-diastole, LVIDs LV internal dimension at end-systole, LVPWd LV posterior wall thickness at end-diastole, LVPWs LV posterior wall thickness at end-systole, EF ejection fraction, FS fractional shortening, CO cardiac output. Age-matched +/+ Veh, lean rats treated with vehicle; +/+ LIRA, lean rats treated with LIRA (0.1 mg/kg/day); fa/fa Veh, obese rats treated with vehicle; fa/fa LIRA, obese rats treated with LIRA (0.1 mg/kg/day)
  2. *p < 0.05 vs lean rats