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Table 1 Animal characteristics, heart mass and renal function of Zucker rats after LIRA treatment on a high-salt diet

From: Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet

ParameterGroup2-way ANOVA p value
+/+ Veh+/+ LIRAfa/fa Vehfa/fa LIRAGenotypeTreatmentInteraction
BW (g)322.1 ± 5.3324.3 ± 5.8518.0 ± 7.6530.4 ± 14.8< 0.00010.4750.581
BG (mg/dL)11.7 ± 0.311.1 ± 0.313.3 ± 0.910.7 ± 0.60.2110.0230.148
SBP (mmHg)125.9 ± 8.5122.0 ± 2.9132.6 ± 7.3123.5 ± 3.20.0180.3660.182
HW (mg)764.5 ± 22.9755.1 ± 12.0922.4 ± 49.2898.2 ± 17.30.00010.4730.945
HW/BW ratio2.37 ± 0.052.33 ± 0.071.78 ± 0.091.69 ± 0.01< 0.00010.3170.897
GFR (mL/min)1.57 ± 0.081.52 ± 0.050.98 ± 0.191.28 ± 0.050.018< 0.0001< 0.0001
Albumin (mg/L)10.0 ± 1.210.1 ± 1.275.4 ± 11.667.1 ± 14.1< 0.00010.6650.653
Creatinine (mg/L)60.0 ± 6.576.8 ± 4.025.3 ± 4.122.2 ± 3.2< 0.00010.1060.069
A/C ratio (mg/g)17.7 ± 3.213.3 ± 1.8327.0 ± 71.1285.9 ± 46.1< 0.00010.4330.499
BUN (mg/dL)13.9 ± 1.113.9 ± 0.616.7 ± 0.614.2 ± 0.50.0610.0320.110
Serum albumin (g/dL)2.85 ± 0.12.86 ± 0.13.62 ± 0.23.64 ± 0.05< 0.00010.1890.033
  1. A/C albumin creatinine ratio, BG blood glucose, BUN blood urea nitrogen, BW body weight, GFR glomerular filtration rate, HW heart weight, HW/BW ratio of heart weight to body weight, SBP systolic blood pressure. Age-matched +/+ Veh, lean rats treated with vehicle; +/+ LIRA, lean rats treated with LIRA (0.1 mg/kg/day); fa/fa Veh, obese rats treated with vehicle; fa/fa LIRA, obese rats treated with LIRA (0.1 mg/kg/day)