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Table 1 Animal characteristics, heart mass and renal function of Zucker rats after LIRA treatment on a high-salt diet

From: Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet

Parameter

Group

2-way ANOVA p value

+/+ Veh

+/+ LIRA

fa/fa Veh

fa/fa LIRA

Genotype

Treatment

Interaction

BW (g)

322.1 ± 5.3

324.3 ± 5.8

518.0 ± 7.6

530.4 ± 14.8

< 0.0001

0.475

0.581

BG (mg/dL)

11.7 ± 0.3

11.1 ± 0.3

13.3 ± 0.9

10.7 ± 0.6

0.211

0.023

0.148

SBP (mmHg)

125.9 ± 8.5

122.0 ± 2.9

132.6 ± 7.3

123.5 ± 3.2

0.018

0.366

0.182

HW (mg)

764.5 ± 22.9

755.1 ± 12.0

922.4 ± 49.2

898.2 ± 17.3

0.0001

0.473

0.945

HW/BW ratio

2.37 ± 0.05

2.33 ± 0.07

1.78 ± 0.09

1.69 ± 0.01

< 0.0001

0.317

0.897

GFR (mL/min)

1.57 ± 0.08

1.52 ± 0.05

0.98 ± 0.19

1.28 ± 0.05

0.018

< 0.0001

< 0.0001

Albumin (mg/L)

10.0 ± 1.2

10.1 ± 1.2

75.4 ± 11.6

67.1 ± 14.1

< 0.0001

0.665

0.653

Creatinine (mg/L)

60.0 ± 6.5

76.8 ± 4.0

25.3 ± 4.1

22.2 ± 3.2

< 0.0001

0.106

0.069

A/C ratio (mg/g)

17.7 ± 3.2

13.3 ± 1.8

327.0 ± 71.1

285.9 ± 46.1

< 0.0001

0.433

0.499

BUN (mg/dL)

13.9 ± 1.1

13.9 ± 0.6

16.7 ± 0.6

14.2 ± 0.5

0.061

0.032

0.110

Serum albumin (g/dL)

2.85 ± 0.1

2.86 ± 0.1

3.62 ± 0.2

3.64 ± 0.05

< 0.0001

0.189

0.033

  1. A/C albumin creatinine ratio, BG blood glucose, BUN blood urea nitrogen, BW body weight, GFR glomerular filtration rate, HW heart weight, HW/BW ratio of heart weight to body weight, SBP systolic blood pressure. Age-matched +/+ Veh, lean rats treated with vehicle; +/+ LIRA, lean rats treated with LIRA (0.1 mg/kg/day); fa/fa Veh, obese rats treated with vehicle; fa/fa LIRA, obese rats treated with LIRA (0.1 mg/kg/day)
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Cardiovascular Diabetology

ISSN: 1475-2840