Skip to main content
Fig. 9 | Cardiovascular Diabetology

Fig. 9

From: Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet

Fig. 9

Proposed schematic representation for the beneficial effects of LIRA in coronary dysfunction associated with the additive effects of obesity and a high-salt diet. High-salt diet induced coronary dysfunction is characterized by increased RNS-production, inflammation and reduced NO bioavailability. LIRA treatment improved endothelial function, oxidative stress and inflammation. These effects are mediated through the downregulation of ET-1, TGF-β1 and upregulation of eNOS and to a variable extent VEGF

Back to article page

Cardiovascular Diabetology

ISSN: 1475-2840