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Table 5 Associations of mtDNA 8-OHdG with 11 cardiovascular biomarkers in patients with T2DM

From: Mitochondrial 8-hydroxy-2′-deoxyguanosine and coronary artery disease in patients with type 2 diabetes mellitus

VariablesAll participantsAfter PS matching
Nβ (95% CI)aPaNβ (95% CI)aPa
Blood lipids
 TG (mmol/L)19200.035 (− 0.007, 0.078)0.10013460.046 (− 0.006, 0.098)0.081
 TC (mmol/L)19200.002 (− 0.044, 0.048)0.9251346− 0.001 (− 0.057, 0.054)0.962
 LDL-c (mmol/L)19200.014 (− 0.023, 0.050)0.4621346− 0.008 (− 0.020, 0.005)0.251
 HDL-c (mmol/L)1920− 0.010 (− 0.020, 0.000)0.05913460.011 (− 0.032, 0.053)0.498
Blood glucose
 FPG (mmol/L)19200.040 (− 0.038, 0.118)0.31913460.001 (− 0.085, 0.087)0.987
 HbA1c (%)19200.000 (− 0.053, 0.053)0.9961346− 0.038 (− 0.148, 0.071)0.492
Blood pressure
 SBP (mmHg)19201.971 (− 0.210, 4.043)0.07713461.297 (− 0.186, 2.780)0.086
 DBP (mmHg)19200.725 (− 0.124, 1.575)0.09413460.718 (− 0.277, 1.714)0.157
Inflammation
 CRP (mg/L)19200.182 (0.055, 0.309)0.00513460.172 (0.028, 0.315)0.019
 D-dimer (mg/L)1798− 0.019 (− 0.067, 0.028)0.43112580.000 (− 0.057, 0.055)0.980
Adiposity
 BMI (m/kg2)19200.068 (− 0.016, 0.153)0.11113460.045 (− 0.162, − 0.252)0.670
  1. Italic values indicate significant results with P < 0.05
  2. BMI body mass index, FPG fasting plasma glucose, HbA1c glycosylated haemoglobin, TC total cholesterol, LDL-c low-density lipoprotein cholesterol, HDL-c high-density lipoprotein cholesterol, TG triglycerides, SBP systolic blood pressure, DBP diastolic blood pressure, CRP C-reactive protein
  3. aMultivariable linear regression was performed with the mtDNA 8-OHdG as the independent variable and each cardiovascular biomarker as the dependent variable, with adjustment for age, sex, smoking habit, alcohol drinking habit, overweight/obesity, hypertension, dyslipidemia., diabetes duration, and type of diabetes management