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Table 4 Associations of mtDNA 8-OHdG with coronary stenosis severity as determined by the number of disease vessels and quartiles of modified Gensini scores

From: Mitochondrial 8-hydroxy-2′-deoxyguanosine and coronary artery disease in patients with type 2 diabetes mellitus

mtDNA 8-OHdGNo. of diseased vessels with > 50% stenosisOR (95% CI)aQuartiles of modified Gensini scoresbOR (95% CI)a
Non-CAD123/LMCADQ1Q2Q3Q4
All participants
 Each 1-SD increase8664483372691.29 (1.19–1.41)4864784824741.28 (1.18–1.39)
 Quartiles, N (%)
  Q1261 (30.1)97 (21.7)86 (25.5)49 (18.2)1 (Reference)149 (30.6)137 (28.7)117 (24.3)90 (19.0)1 (Reference)
  Q2251 (29.0)108 (24.1)59 (17.5)57 (21.2)0.92 (0.72–1.18)132 (27.2)130 (27.2)116 (24.0)97 (20.4)1.08 (0.86–1.36)
  Q3213 (24.6)104 (23.2)85 (25.2)78 (29.0)1.33 (1.06–1.69)115 (23.7)110 (23.0)131 (27.2)124 (26.2)1.42 (1.13–1.78)
  Q4141 (16.3)139 (31.0)107 (31.8)85 (31.6)1.91 (1.50–2.42)90 (18.5)101 (21.1)118 (24.5)163 (34.4)1.94 (1.54–2.44)
 P for trend    < 0.001    < 0.001
After PS matching
 Each 1-SD increase6732952111671.36 (1.22–1.50)3583642883361.33 (1.21–1.47)
 Quartiles
  Q1187 (27.8)69 (23.4)56 (26.5)24 (14.4)1 (Reference)98 (27.4)108 (29.7)77 (26.8)53 (15.8)1 (Reference)
  Q2190 (28.2)71 (24.0)38 (18.0)39 (23.4)0.98 (0.73–1.31)95 (26.5)103 (28.3)66 (22.9)74 (22.0)1.12 (0.85–1.48)
  Q3176 (26.2)63 (21.4)54 (25.6)46 (27.5)1.27 (0.95–1.70)87 (24.3)80 (22.0)85 (29.5)87 (25.9)1.49 (1.14–1.96)
  Q4120 (17.8)92 (31.2)63 (29.9)58 (34.7)2.04 (1.53–2.72)78 (21.8)73 (20.0)60 (20.8)122 (36.3)2.01 (1.52–2.65)
 P for trend    < 0.001     
  1. PS propensity score, 8-OHdG 8-hydroxy-2′-deoxyguanosine, LMCAD left main coronary artery disease
  2. aModels were adjusted for age, sex, smoking habit, alcohol drinking habit, overweight/obesity, hypertension, dyslipidemia., FPG, HbA1c, diabetes duration, and type of diabetes management
  3. bThe median (interquartile range) of modified Gensini scores before and after PS matching was 27 (20–36) and 27 (20–35.5), respectively