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Table 4 Associations of mtDNA 8-OHdG with coronary stenosis severity as determined by the number of disease vessels and quartiles of modified Gensini scores

From: Mitochondrial 8-hydroxy-2′-deoxyguanosine and coronary artery disease in patients with type 2 diabetes mellitus

mtDNA 8-OHdG

No. of diseased vessels with > 50% stenosis

OR (95% CI)a

Quartiles of modified Gensini scoresb

OR (95% CI)a

Non-CAD

1

2

3/LMCAD

Q1

Q2

Q3

Q4

All participants

 Each 1-SD increase

866

448

337

269

1.29 (1.19–1.41)

486

478

482

474

1.28 (1.18–1.39)

 Quartiles, N (%)

  Q1

261 (30.1)

97 (21.7)

86 (25.5)

49 (18.2)

1 (Reference)

149 (30.6)

137 (28.7)

117 (24.3)

90 (19.0)

1 (Reference)

  Q2

251 (29.0)

108 (24.1)

59 (17.5)

57 (21.2)

0.92 (0.72–1.18)

132 (27.2)

130 (27.2)

116 (24.0)

97 (20.4)

1.08 (0.86–1.36)

  Q3

213 (24.6)

104 (23.2)

85 (25.2)

78 (29.0)

1.33 (1.06–1.69)

115 (23.7)

110 (23.0)

131 (27.2)

124 (26.2)

1.42 (1.13–1.78)

  Q4

141 (16.3)

139 (31.0)

107 (31.8)

85 (31.6)

1.91 (1.50–2.42)

90 (18.5)

101 (21.1)

118 (24.5)

163 (34.4)

1.94 (1.54–2.44)

 P for trend

    

< 0.001

    

< 0.001

After PS matching

 Each 1-SD increase

673

295

211

167

1.36 (1.22–1.50)

358

364

288

336

1.33 (1.21–1.47)

 Quartiles

  Q1

187 (27.8)

69 (23.4)

56 (26.5)

24 (14.4)

1 (Reference)

98 (27.4)

108 (29.7)

77 (26.8)

53 (15.8)

1 (Reference)

  Q2

190 (28.2)

71 (24.0)

38 (18.0)

39 (23.4)

0.98 (0.73–1.31)

95 (26.5)

103 (28.3)

66 (22.9)

74 (22.0)

1.12 (0.85–1.48)

  Q3

176 (26.2)

63 (21.4)

54 (25.6)

46 (27.5)

1.27 (0.95–1.70)

87 (24.3)

80 (22.0)

85 (29.5)

87 (25.9)

1.49 (1.14–1.96)

  Q4

120 (17.8)

92 (31.2)

63 (29.9)

58 (34.7)

2.04 (1.53–2.72)

78 (21.8)

73 (20.0)

60 (20.8)

122 (36.3)

2.01 (1.52–2.65)

 P for trend

    

< 0.001

     
  1. PS propensity score, 8-OHdG 8-hydroxy-2′-deoxyguanosine, LMCAD left main coronary artery disease
  2. aModels were adjusted for age, sex, smoking habit, alcohol drinking habit, overweight/obesity, hypertension, dyslipidemia., FPG, HbA1c, diabetes duration, and type of diabetes management
  3. bThe median (interquartile range) of modified Gensini scores before and after PS matching was 27 (20–36) and 27 (20–35.5), respectively