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Table 2 Association of mtDNA 8-OHdG with CAD risk in patients with T2DM

From: Mitochondrial 8-hydroxy-2′-deoxyguanosine and coronary artery disease in patients with type 2 diabetes mellitus

mtDNA 8-OHdG

Obstructive CAD N (%)

Non-CAD

N (%)

OR (95%CI)

Model 1a

Model 2b

Model 3c

All participants

 Each 1-SD increase

1054

866

1.41 (1.28–1.56)

1.38 (1.25–1.53)

1.38 (1.24–1.52)

 Quartiles

  Q1 (< 2.84)

232 (22.0)

261 (30.1)

1 (Reference)

1 (Reference)

1 (Reference)

  Q2 (2.84–3.20)

224 (21.3)

251 (29.0)

1.00 (0.78–1.29)

0.94 (0.72–1.22)

0.93 (0.71–1.22)

  Q3 (3.20–3.53)

267 (25.3)

213 (24.6)

1.41 (1.10–1.82)

1.33 (1.02–1.73)

1.32 (1.01–1.72)

  Q4 (> 3.53)

331 (31.4)

141 (16.3)

2.64 (2.03–3.44)

2.42 (1.84–3.19)

2.41 (1.82–3.19)

 P for trend

  

< 0.001

< 0.001

< 0.001

After PS matching

 Each 1-SD increase

673

673

1.39 (1.24–1.56)

1.39 (1.24–1.55)

1.39 (1.24–1.55)

 Quartiles

  Q1 (< 2.84)

149 (22.1)

187 (27.8)

1 (Reference)

1 (Reference)

1 (Reference)

  Q2 (2.84–3.17)

148 (22.0)

190 (28.2)

0.98 (0.72–1.33)

0.97 (0.71–1.31)

0.94 (0.69–1.28)

  Q3 (3.17–3.52)

163 (24.2)

176 (26.2)

1.16 (0.86–1.57)

1.16 (0.86–1.57)

1.17 (0.86–1.58)

  Q4 (> 3.52)

213 (31.7)

120 (17.8)

2.22 (1.63–3.04)

2.19 (1.60–3.00)

2.18 (1.60–2.99)

 P for trend

  

< 0.001

< 0.001

< 0.001

  1. PS propensity score, 8-OHdG 8-hydroxy-2′-deoxyguanosine, CAD coronary artery disease
  2. aCrude model without any confounders
  3. bModel 2 was adjusted for age, sex, smoking habit, alcohol drinking habit, overweight/obesity, hypertension, and dyslipidemia
  4. cModel 3 was adjusted for age, sex, smoking habit, alcohol drinking habit, overweight/obesity, hypertension, dyslipidemia., FPG, HbA1c, diabetes duration, and type of diabetes management