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Table 2 Association of mtDNA 8-OHdG with CAD risk in patients with T2DM

From: Mitochondrial 8-hydroxy-2′-deoxyguanosine and coronary artery disease in patients with type 2 diabetes mellitus

mtDNA 8-OHdGObstructive CAD N (%)Non-CAD
N (%)
OR (95%CI)
Model 1aModel 2bModel 3c
All participants
 Each 1-SD increase10548661.41 (1.28–1.56)1.38 (1.25–1.53)1.38 (1.24–1.52)
 Quartiles
  Q1 (< 2.84)232 (22.0)261 (30.1)1 (Reference)1 (Reference)1 (Reference)
  Q2 (2.84–3.20)224 (21.3)251 (29.0)1.00 (0.78–1.29)0.94 (0.72–1.22)0.93 (0.71–1.22)
  Q3 (3.20–3.53)267 (25.3)213 (24.6)1.41 (1.10–1.82)1.33 (1.02–1.73)1.32 (1.01–1.72)
  Q4 (> 3.53)331 (31.4)141 (16.3)2.64 (2.03–3.44)2.42 (1.84–3.19)2.41 (1.82–3.19)
 P for trend  < 0.001< 0.001< 0.001
After PS matching
 Each 1-SD increase6736731.39 (1.24–1.56)1.39 (1.24–1.55)1.39 (1.24–1.55)
 Quartiles
  Q1 (< 2.84)149 (22.1)187 (27.8)1 (Reference)1 (Reference)1 (Reference)
  Q2 (2.84–3.17)148 (22.0)190 (28.2)0.98 (0.72–1.33)0.97 (0.71–1.31)0.94 (0.69–1.28)
  Q3 (3.17–3.52)163 (24.2)176 (26.2)1.16 (0.86–1.57)1.16 (0.86–1.57)1.17 (0.86–1.58)
  Q4 (> 3.52)213 (31.7)120 (17.8)2.22 (1.63–3.04)2.19 (1.60–3.00)2.18 (1.60–2.99)
 P for trend  < 0.001< 0.001< 0.001
  1. PS propensity score, 8-OHdG 8-hydroxy-2′-deoxyguanosine, CAD coronary artery disease
  2. aCrude model without any confounders
  3. bModel 2 was adjusted for age, sex, smoking habit, alcohol drinking habit, overweight/obesity, hypertension, and dyslipidemia
  4. cModel 3 was adjusted for age, sex, smoking habit, alcohol drinking habit, overweight/obesity, hypertension, dyslipidemia., FPG, HbA1c, diabetes duration, and type of diabetes management