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Fig. 2 | Cardiovascular Diabetology

Fig. 2

From: Increased risk of cardiovascular mortality by strict glycemic control (pre-procedural HbA1c < 6.5%) in Japanese medically-treated diabetic patients following percutaneous coronary intervention: a 10-year follow-up study

Fig. 2

Adjusted hazard ratios for incidence of cardiovascular death by HbA1c categories in different models. a Model 1: Hazard ratios by categorized HbA1c adjusted by age (1 year older), gender male, number of diseased vessels, systolic blood pressure (1SD higher), LDL-cholesterol (1SD higher), HDL-cholesterol (1SD higher), blood glucose (1SD higher) and diabetes duration (1 year longer). U-shaped risk for cardiovascular death by categorized HbA1c level; the risk was lowest in the group with HbA1c 7.0–7.5%. Compared with that group, the risk of HbA1c < 6.5% was significantly higher. b Model 2: Hazard ratios by categorized HbA1c adjusted by age (1 year older), gender male, use of beta-blockers, ejection fraction (1SD higher), serum hemoglobin (1SD higher), blood glucose (1SD higher), eGFR (1SD higher), diabetes duration (1 year longer) and insulin use. Consistent with Model 1, a U-shaped relationship between preprocedural HbA1c and risk of cardiovascular mortality is shown. The lowest hazard ratio was observed in the group with HbA1c 7.0–7.5%. HbA1c glycated hemoglobin (%), SD standard deviation, eGFR estimated glomerular filtration rate

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