Atrial fibrillation | Hazard ratio (95% CI) p-value | ||
---|---|---|---|
Model 1 | Model 2 | Model 3 | |
Time updated mean HbA1c categories and albuminuria | n events = 179,166 N subjects = 2,471,982 Data used = 96.8% | n events = 175,683 N subjects = 2,429,261 Data used = 95.2% | n events = 173,899 N subjects = 2,408,243 Data used = 94.3% |
 Controls (reference) | 1.00 | 1.00 | 1.00 |
 ≤ 6.9% (≤ 52 mmol/mol)–normoalbuminuria | 1.22 (1.20–1.24) < 0.0001 | 1.17 (1.15–1.20) < 0.0001 | 1.16 (1.14–1.19) < 0.0001 |
 7.0–7.8% (53–62 mmol/mol)–normoalbuminuria | 1.22 (1.19–1.25) < 0.0001 | 1.16 (1.13–1.20) < 0.0001 | 1.16 (1.13–1.19) < 0.0001 |
 7.9–8.7% (63–72 mmol/mol)–normoalbuminuria | 1.30 (1.24–1.35) < 0.0001 | 1.23 (1.17–1.28) < 0.0001 | 1.24 (1.18–1.29) < 0.0001 |
 8.8–9.6% (73–82 mmol/mol)–Normoalbuminuria | 1.40 (1.30–1.51) < 0.0001 | 1.32 (1.23–1.43) < 0.0001 | 1.31 (1.21–1.42) < 0.0001 |
 ≥ 9.7% (≥ 83 mmol/mol)–normoalbuminuria | 1.43 (1.28–1.61) < 0.0001 | 1.35 (1.20–1.51) < 0.0001 | 1.35 (1.20–1.52) < 0.0001 |
 ≤ 6.9% (≤ 52 mmol/mol)–Not normoalbuminuria | 1.68 (1.63–1.73) < 0.0001 | 1.56 (1.52–1.61) < 0.0001 | 1.55 (1.50–1.60) < 0.0001 |
 7.0–7.8% (53–62 mmol/mol)–Not normoalbuminuria | 1.72 (1.67–1.79) < 0.0001 | 1.62 (1.56–1.67) < 0.0001 | 1.61 (1.55–1.67) < 0.0001 |
 7.9–8.7% (63–72 mmol/mol)–Not normoalbuminuria | 1.86 (1.77–1.95) < 0.0001 | 1.72 (1.64–1.81) < 0.0001 | 1.73 (1.64–1.82) < 0.0001 |
 8.8–9.6% (73–82 mmol/mol)–Not normoalbuminuria | 2.04 (1.90–2.20) < 0.0001 | 1.85 (1.71–1.99) < 0.0001 | 1.85 (1.71–2.00) < 0.0001 |
 ≥ 9.7% (≥ 83 mmol/mol)–Not normoalbuminuria | 2.20 (1.97–2.45) < 0.0001 | 2.00 (1.79–2.23) < 0.0001 | 2.04 (1.82–2.28) < 0.0001 |
Time updated mean HbA1c categories and eGFR | n events = 182,743 N subjects = 2,522,210 Data used = 98.8% | n events = 179,127 N subjects = 2,477,785 Data used = 97.1% | n events = 176,733 N subjects = 2,447,085 Data used = 95.8% |
 Controls (reference) | 1.00 | 1.00 | 1.00 |
 ≤ 6.9% (≤ 52 mmol/mol) –eGFR ≥ 60 | 1.26 (1.24–1.29) < 0.0001 | 1.22 (1.20–1.25) < 0.0001 | 1.21 (1.19–1.24) < 0.0001 |
 7.0–7.8% (53- 62 mmol/mol)–eGFR ≥ 60 | 1.29 (1.26–1.32) < 0.0001 | 1.24 (1.21–1.28) < 0.0001 | 1.24 (1.20–1.27) < 0.0001 |
 7.9–8.7% (63–72 mmol/mol)–eGFR ≥ 60 | 1.38 (1.33–1.44) < 0.0001 | 1.33 (1.27–1.38) < 0.0001 | 1.33 (1.27–1.39) < 0.0001 |
 8.8–9.6% (73–82 mmol/mol)–eGFR ≥ 60 | 1.51 (1.41–1.61) < 0.0001 | 1.43 (1.34–1.53) < 0.0001 | 1.41 (1.32–1.52) < 0.0001 |
 ≥ 9.7% (≥ 83 mmol/mol)–eGFR >=60 | 1.55 (1.42–1.71) < 0.0001 | 1.51 (1.38–1.66) < 0.0001 | 1.52 (1.38–1.68) < 0.0001 |
 ≤ 6.9% (≤ 52 mmol/mol)–eGFR < 60 | 1.45 (1.42–1.49) < 0.0001 | 1.33 (1.30–1.37) <  0.0001 | 1.32 (1.28–1.36) < 0.0001 |
 7.0–7.8% (53–62 mmol/mol)–eGFR < 60 | 1.54 (1.49–1.60) < 0.0001 | 1.41 (1.36–1.46) < 0.0001 | 1.40 (1.35–1.45) < 0.0001 |
 7.9–8.7% (63–72 mmol/mol)–eGFR < 60 | 1.73 (1.65–1.81) < 0.0001 | 1.55 (1.47–1.62) < 0.0001 | 1.56 (1.48–1.65) < 0.0001 |
 8.8–9.6% (73–82 mmol/mol)–eGFR < 60 | 1.87 (1.72–2.03) < 0.0001 | 1.64 (1.51–1.79) < 0.0001 | 1.65 (1.51–1.80) < 0.0001 |
 ≥ 9.7% (≥ 83 mmol/mol)–eGFR < 60 | 1.98 (1.74–2.25) < 0.0001 | 1.71 (1.50–1.95) < 0.0001 | 1.75 (1.53–2.00) < 0.0001 |
Time updated mean HbA1c categories albuminuria and eGFR | n events = 179,980 N subjects = 2,480,217 Data used = 97.1% | n events = 176,459 N subjects = 2,437,158 Data used = 95.5% | n events = 174,466 N subjects = 2,414,092 Data used = 94.6% |
 Controls (reference) | 1.00 | 1.00 | 1.00 |
 ≤ 6.9% (≤ 52 mmol/mol)–Normoalbuminuria and eGFR ≥60 | 1.19 (1.16–1.22) < 0.0001 | 1.16 (1.13–1.19) < 0.0001 | 1.15 (1.12–1.18) < 0.0001 |
 7.0–7.8% (53–62 mmol/mol)–Normoalbuminuria and  eGFR ≥ 60 | 1.17 (1.14–1.21) < 0.0001 | 1.14 (1.10–1.18) < 0.0001 | 1.13 (1.09–1.17) < 0.0001 |
 7.9–8.7% (63–72 mmol/mol)–Normoalbuminuria and eGFR ≥ 60 | 1.22 (1.16–1.29) < 0.0001 | 1.17 (1.11–1.24) < 0.0001 | 1.19 (1.13–1.26) < 0.0001 |
 8.8–9.6% (73–82 mmol/mol)–Normoalbuminuria and eGFR ≥ 60 | 1.30 (1.18–1.43) < 0.0001 | 1.25 (1.14–1.38) < 0.0001 | 1.25 (1.13–1.38) < 0.0001 |
 ≥ 9.7% (≥ 83 mmol/mol)–Normoalbuminuria and eGFR ≥ 60 | 1.40 (1.22–1.62) < 0.0001 | 1.35 (1.16–1.56) < 0.0001 | 1.33 (1.14–1.55) < 0.0002 |
 ≤ 6.9% (≤ 52 mmol/mol)–Not Normoalbuminuria or eGFR < 60 | 1.50 (1.47–1.53) < 0.0001 | 1.39 (1.36–1.42) < 0.0001 | 1.38 (1.34–1.41) < 0.0001 |
 7.0–7.8% (53–62 mmol/mol)–Not Normoalbuminuria or eGFR < 60 | 1.57 (1.52–1.61) < 0.0001 | 1.45 (1.41–1.49) < 0.0001 | 1.45 (1.41–1.50) < 0.0001 |
 7.9–8.7% (63–72 mmol/mol)–Not Normoalbuminuria or eGFR < 60 | 1.75 (1.68–1.81) < 0.0001 | 1.60 (1.54–1.66) < 0.0001 | 1.61 (1.55–1.68) < 0.0001 |
 8.8–9.6% (73–82 mmol/mol)–Not Normoalbuminuria or eGFR < 60 | 1.90 (1.79–2.03) < 0.0001 | 1.71 (1.60–1.82) < 0.0001 | 1.72 (1.61–1.84) < 0.0001 |
 ≥ 9.7% (≥ 83 mmol/mol)–Not Normoalbuminuria or eGFR < 60 | 2.03 (1.85–2.23) < 0.0001 | 1.84 (1.67–2.02) < 0.0001 | 1.88 (1.71–2.08) < 0.0001 |