Table 3 Adjusted hazard ratios for atrial fibrillation and 95% confidence intervals for time-updated mean HbA1c categories, albuminuria categories and eGFR categories versus the reference group examined by Cox regression

Time updated mean HbA1c categories

n events = 185,793 

N subjects = 2,544,103

data used = 99.6%

n events = 182,081 

N subjects = 2,498,727

data used = 97.9%

n events = 179,445 

N subjects = 2,465,540

data used = 96.6%

 Controls (reference)

1.00

1.00

1.00

 ≤ 6.9% (≤ 52 mmol/mol)

1.32 (1.30–1.34) < 0.0001

1.26 (1.24–1.27) < 0.0001

1.24 (1.22–1.26) < 0.0001

 7.0–7.8% (53–62 mmol/mol)

1.36 (1.34–1.39) < 0.0001

1.29 (1.27–1.32) < 0.0001

1.28 (1.25–1.31) < 0.0001

 7.9–8.7% (63–72 mmol/mol)

1.47 (1.43–1.52) < 0.0001

1.38 (1.34–1.42) < 0.0001

1.38 (1.34–1.42) < 0.0001

 8.8–9.6% (73–82 mmol/mol)

1.61 (1.54–1.69) < 0.0001

1.49 (1.42–1.57) < 0.0001

1.47 (1.40–1.55) < 0.0001

 ≥ 9.7% (≥ 83 mmol/mol)

1.65 (1.55–1.77) < 0.0001

1.56 (1.46–1.68) < 0.0001

1.57 (1.46–1.68) < 0.0001

Time updated albuminuria categories

n events = 179,380 

N subjects = 2,473,810

Data used = 96.9%

n events = 175,890 

N subjects = 2,431,009

Data used = 95.2%

n events = 174,059 

N subjects = 2,409,479

Data used = 94.4%

 Controls (reference)

1.00

1.00

1.00

 Normoalbuminuria

1.24 (1.22–1.25) < 0.0001

1.18 (1.17–1.20) < 0.0001

1.17 (1.16–1.19) < 0.0001

 Microalbuminuria

1.63 (1.59–1.67) < 0.0001

1.54 (1.50–1.58) < 0.0001

1.52 (1.48–1.56) < 0.0001

 Macroalbuminuria

1.91 (1.85–1.97) < 0.0001

1.75 (1.69–1.80) < 0.0001

1.74 (1.68–1.80) < 0.0001

 CKD stage 5

3.73 (3.32–4.20) < 0.0001

3.23 (2.87–3.64) < 0.0001

3.24 (2.86–3.66)

< 0.0001

Time updated eGFR categories

n events = 183,107 

N subjects = 2,525,557

Data used = 98.9%

n events = 179,482 

N subjects = 2,481,018

Data used = 97.2%

n events = 176,958 

N subjects = 2,449,089

Data used = 95.9%

 Controls (reference)

1.00

1.00

1.00

 CKD stage 1 (eGFR ≥ 90)

1.38 (1.34–1.42) < 0.0001

1.35 (1.31–1.39) < 0.0001

1.33 (1.29–1.37) < 0.0001

 CKD stage 2 (eGFR 60–89)

1.28 (1.26–1.30) < 0.0001

1.23 (1.21–1.25) < 0.0001

1.22 (1.20–1.24) < 0.0001

 CKD stage 3 (eGFR 30–59)

1.47 (1.44–1.50) < 0.0001

1.34 (1.32–1.37) < 0.0001

1.33 (1.30–1.36) < 0.0001

 CKD stage 4 (eGFR 15–29)

2.09 (1.98–2.21) < 0.0001

1.78 (1.68–1.88) < 0.0001

1.76 (1.66–1.87) < 0.0001

 CKD stage 5 (eGFR < 15 or dialysis)

3.77 (3.36–4.25) < 0.0001

3.27 (2.91–3.69) < 0.0001

3.24 (2.87–3.67) < 0.0001