Table 3 Pairwise comparisons (with Bonferroni correction) for those endpoints with significant differences between the three treatments on ANOVA

20.46 (16.33 to 24.58)

< 0.001

31.24 (26.79 to 35.68)

< 0.001

10.78 (7.34 to 14.22)

< 0.001

23.04 (17.17 to 29.91)

< 0.001

39.96 (35.75 to 44.18)

< 0.001

16.93 (12.48 to 21.00)

< 0.001

21.80 (16.01 to 27.59)

< 0.001

43.07 (38.54 to 47.60)

< 0.001

21.27 (16.75 to 25.80)

< 0.001

22.29 (15.97 to 28.61)

< 0.001

46.86 (41.39 to 52.32)

< 0.001

24.56 (28.98 to 20.14)

< 0.001

19.94 (13.71 to 26.14)

< 0.001

43.53 (38.57 to 48.49)

< 0.001

23.60 (19.34 to 27.83)

< 0.001

− 56.86 (− 68.89 to − 44.82)

< 0.001

− 45.98 (− 56.77 to − 35.20)

< 0.001

10.87 (0.95 to 20.79)

0.027

− 10.24 (− 16.52 to − 3.95)

0.001

1.86 (− 3.22 to 6.92)

> 0.99

12.09 (7.52 to 16.66)

< 0.001

0.62 (− 2.28 to 3.52)

> 0.99

5.73 (2.71 to 8.74)

< 0.001

5.11 (1.48 to 8.74)

0.003

5.87 (2.05 to 9.69)

0.001

12.52 (8.32 to 16.72)

< 0.001

6.65 (3.65 to 9.65)

< 0.001

13.00 (6.56 to 19.43)

< 0.001

22.23 (16.00 to 28.45)

< 0.001

9.23 (5.30 to 13.16)

< 0.001

14.27 (6.95 to 21.58)

< 0.001

27.37 (19.63 to 35.11)

< 0.001

13.10 (8.19 to 18.01)

< 0.001

17.28 (9.90 to 24.66)

< 0.001

29.95 (22.17 to 37.74)

< 0.001

12.67 (7.55 to 17.80)

< 0.001

18.02 (9.82 to 26.22)

< 0.001

30.97 (23.13 to 38.81)

< 0.001

12.95 (7.22 to 18.68)

< 0.001

− 23.61 (− 56.2 to 8.98)

0.237

18.28 (− 8.57 to 45.12)

0.295

41.8 (7.41 to 76.37)

0.012