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Table 2 Results of study endpoints relating to platelet function, P-selectin expression, fibrin clot dynamics, coagulation-associated proteins and inflammatory markers

From: Aspirin, clopidogrel and prasugrel monotherapy in patients with type 2 diabetes mellitus: a double-blind randomised controlled trial of the effects on thrombotic markers and microRNA levels

  Aspirin (n = 56)Clopidogrel (n = 56)Prasugrel (n = 56)p
Mean ± SDMean ± SDMean ± SD
Maximum platelet aggregation response (%)
Agonist[Agonist] 
 ADP1 μmol/L42.7 ± 15.622.3 ± 12.911.5 ± 8.1< 0.001
2 μmol/L61.0 ± 12.437.9 ± 17.021.0 ± 11.4< 0.001
5 μmol/L71.0 ± 8.949.2 ± 17.027.9 ± 12.8< 0.001
10 μmol/L80.5 ± 9.758.2 ± 18.133.6 ± 14.3< 0.001
20 μmol/L77.6 ± 8.457.7 ± 17.634.1 ± 14.1< 0.001
 AA1 mmol/L6.6 ± 19.063.4 ± 34.652.6 ± 31.1< 0.001
 Collagen2 μg/mL62.1 ± 19.472.3 ± 18.260.2 ± 18.5< 0.001
16 μg/mL84.4 ± 7.083.8 ± 8.178.6 ± 9.4< 0.001
Platelet P-selectin expression (%)
[ADP] (μmol/L) 
 0.318.4 ± 13.012.5 ± 10.45.9 ± 5.0< 0.001
 131.2 ± 19.018.2 ± 14.59.0 ± 6.8< 0.001
 337.8 ± 23.123.5 ± 17.310.4 ± 7.7< 0.001
 1041.5 ± 23.724.2 ± 17.611.5 ± 8.1< 0.001
 3045.1 ± 21.427.1 ± 19.014.1 ± 14.9< 0.001
Fibrin clot dynamics
 Lag time(s)683.3 ± 170.4706.9 ± 196.2665.0 ± 151.80.007
 Maximum absorbance(AU)0.2 ± 0.080.2 ± 0.090.2 ± 0.080.65
 Lysis time(s)519.6 ± 112.3522.3 ± 132.8522.4 ± 101.20.95
Coagulation-associated proteins
 Fibrinogen(g/L)2.8 ± 0.52.7 ± 0.52.7 ± 0.50.69
 PAI-1(pg/mL)2334.6 ± 1675.32132.5 ± 1626.42089.3 ± 1667.10.27
Inflammatory markers
 WCC(×106/L)7.2 ± 1.86.7 ± 1.97.0 ± 2.00.067
 CRP(mg/L)2.3 ± 3.42.4 ± 4.61.8 ± 2.20.5
 C3(g/L)0.7 ± 0.10.7 ± 0.10.7 ± 0.10.27
  1. p values represent a repeated-measures ANOVA conducted between the three treatments
  2. AA arachidonic acid, C3 complement fragment 3, PAI-1 plasminogen activator inhibitor 1, WCC white cell count