Table 2 Results of study endpoints relating to platelet function, P-selectin expression, fibrin clot dynamics, coagulation-associated proteins and inflammatory markers
|  |  | Aspirin (n = 56) | Clopidogrel (n = 56) | Prasugrel (n = 56) | p |
|---|---|---|---|---|---|
Mean ± SD | Mean ± SD | Mean ± SD | |||
Maximum platelet aggregation response (%) | |||||
Agonist | [Agonist] | Â | |||
 ADP | 1 μmol/L | 42.7 ± 15.6 | 22.3 ± 12.9 | 11.5 ± 8.1 | < 0.001 |
2 μmol/L | 61.0 ± 12.4 | 37.9 ± 17.0 | 21.0 ± 11.4 | < 0.001 | |
5 μmol/L | 71.0 ± 8.9 | 49.2 ± 17.0 | 27.9 ± 12.8 | < 0.001 | |
10 μmol/L | 80.5 ± 9.7 | 58.2 ± 18.1 | 33.6 ± 14.3 | < 0.001 | |
20 μmol/L | 77.6 ± 8.4 | 57.7 ± 17.6 | 34.1 ± 14.1 | < 0.001 | |
 AA | 1 mmol/L | 6.6 ± 19.0 | 63.4 ± 34.6 | 52.6 ± 31.1 | < 0.001 |
 Collagen | 2 μg/mL | 62.1 ± 19.4 | 72.3 ± 18.2 | 60.2 ± 18.5 | < 0.001 |
16 μg/mL | 84.4 ± 7.0 | 83.8 ± 8.1 | 78.6 ± 9.4 | < 0.001 | |
Platelet P-selectin expression (%) | |||||
[ADP] (μmol/L) |  | ||||
 0.3 | 18.4 ± 13.0 | 12.5 ± 10.4 | 5.9 ± 5.0 | < 0.001 | |
 1 | 31.2 ± 19.0 | 18.2 ± 14.5 | 9.0 ± 6.8 | < 0.001 | |
 3 | 37.8 ± 23.1 | 23.5 ± 17.3 | 10.4 ± 7.7 | < 0.001 | |
 10 | 41.5 ± 23.7 | 24.2 ± 17.6 | 11.5 ± 8.1 | < 0.001 | |
 30 | 45.1 ± 21.4 | 27.1 ± 19.0 | 14.1 ± 14.9 | < 0.001 | |
Fibrin clot dynamics | |||||
 Lag time | (s) | 683.3 ± 170.4 | 706.9 ± 196.2 | 665.0 ± 151.8 | 0.007 |
 Maximum absorbance | (AU) | 0.2 ± 0.08 | 0.2 ± 0.09 | 0.2 ± 0.08 | 0.65 |
 Lysis time | (s) | 519.6 ± 112.3 | 522.3 ± 132.8 | 522.4 ± 101.2 | 0.95 |
Coagulation-associated proteins | |||||
 Fibrinogen | (g/L) | 2.8 ± 0.5 | 2.7 ± 0.5 | 2.7 ± 0.5 | 0.69 |
 PAI-1 | (pg/mL) | 2334.6 ± 1675.3 | 2132.5 ± 1626.4 | 2089.3 ± 1667.1 | 0.27 |
Inflammatory markers | |||||
 WCC | (×106/L) | 7.2 ± 1.8 | 6.7 ± 1.9 | 7.0 ± 2.0 | 0.067 |
 CRP | (mg/L) | 2.3 ± 3.4 | 2.4 ± 4.6 | 1.8 ± 2.2 | 0.5 |
 C3 | (g/L) | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.27 |