From: Sodium–glucose cotransporter 2 inhibitor Dapagliflozin attenuates diabetic cardiomyopathy
Wt/wt | Wt/wt + ATII | Db/db | Db/db + DAPA | Db/db + ATII | Db/db + ATII + DAPA | |
---|---|---|---|---|---|---|
Numbers | 6 | 6 | 5 | 4 | 6 | 6 |
IVS | 0.9 ± 0.1 | 1.2 ± 0.08& | 0.96 ± 0.08 | 0.97 ± 0.1 | 1.2 ± 0.1# | 1.2 ± 0.2 |
LVPW | 0.8 ± 0.05 | 1.1 ± 0.12& | 0.9 ± 0.1 | 0.9 ± 0.3 | 1.1 ± 0.1# | 1.2 ± 0.3 |
LVEDD | 3.8 ± 0.2 | 3.4 ± 0.3 | 3.5 ± 0.5 | 3.7 ± 0.6 | 3.7 ± 0.4 | 3.4 ± 0.6 |
LVESD | 2.4 ± 0.1 | 2.3 ± 0.3 | 2.1 ± 0.5 | 2.2 ± 0.5 | 2.4 ± 0.3 | 1.9 ± 0.5* |
FS | 36.2 ± 2.2 | 31.9 ± 4.9 | 39.4 ± 6.2 | 39.7 ± 6.3 | 34.9 ± 2.6 | 45.9 ± 6.5* |