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Table 5 Subgroup analysis for performance of models predicting MACEs in patients with and without T2DM

From: High-sensitivity troponin I and B-type natriuretic peptide biomarkers for prediction of cardiovascular events in patients with coronary artery disease with and without diabetes mellitus

ModelFeatureT2DM, AUC (95% CI)No T2DM, AUC (95% CI)P value*
Model 2Age ≥ 65 years + Male + hypertension0.60 (0.57–0.63)0.64 (0.59–0.70)0.23
Model 3Model 2 + BNP0.63 (0.59–0.66)0.72 (0.66–0.78)0.009
Model 4Model 2 + hs-Tnl0.64 (0.61–0.67)0.72 (0.66–0.78)0.016
Model 5Model 2 + hs-Tnl + BNP0.64 (0.61–0.68)0.75 (0.69–0.81)<0.001
  1. BNP and hs-Tnl are at levels above optimal cutoffs
  2. AUC area under the curve, BNP B-type natriuretic peptide, CI confidence interval, hs-Tnl high-sensitivity troponin-I, T2DM type 2 diabetes mellitus
  3. *P value from DeLong’s test for difference between AUCs of T2DM versus no T2DM