High-sensitivity troponin I and B-type natriuretic peptide biomarkers for prediction of cardiovascular events in patients with coronary artery disease with and without diabetes mellitus

Table 5 Subgroup analysis for performance of models predicting MACEs in patients with and without T2DM

Model	Feature	T2DM, AUC (95% CI)	No T2DM, AUC (95% CI)	P value*
Model 2	Age ≥ 65 years + Male + hypertension	0.60 (0.57–0.63)	0.64 (0.59–0.70)	0.23
Model 3	Model 2 + BNP	0.63 (0.59–0.66)	0.72 (0.66–0.78)	0.009
Model 4	Model 2 + hs-Tnl	0.64 (0.61–0.67)	0.72 (0.66–0.78)	0.016
Model 5	Model 2 + hs-Tnl + BNP	0.64 (0.61–0.68)	0.75 (0.69–0.81)	<0.001

BNP and hs-Tnl are at levels above optimal cutoffs
AUC area under the curve, BNP B-type natriuretic peptide, CI confidence interval, hs-Tnl high-sensitivity troponin-I, T2DM type 2 diabetes mellitus
*P value from DeLong’s test for difference between AUCs of T2DM versus no T2DM

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