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Table 4 Performance of models predicting MACEs in stable CAD patients

From: High-sensitivity troponin I and B-type natriuretic peptide biomarkers for prediction of cardiovascular events in patients with coronary artery disease with and without diabetes mellitus

ModelFeatureAICNRI (95% CI)P valueIDI (95% CI)P value
Model 2Age ≥ 65 years + Male + T2DM + Hypertension5701.9
Model 3Model 2 + BNP5678.334.5% (23.8–45.1%)< 0.0011.2% (0.7–1.7%)< 0.001
Model 4Model 2 + hs-Tnl5664.534.9% (24.8–45.0%)< 0.0012.4% (1.6–3.2%)< 0.001
Model 5Model 2 + hs-Tnl + BNP5655.529.7% (19.2–40.2%)< 0.0012.9% (2.1–3.8%)< 0.001
  1. Model 2: incorporated variables of age ≥ 65 years, male sex, presence of T2DM and hypertension; Model 3: variables in Model 2 and addition of BNP above optimal cutoff; Model 4: variables in Model 2 and addition of hs-Tnl above optimal cutoff; Model 5: variables in Model 2 and addition of hs-Tnl and BNP above cutoffs
  2. AIC Akaike Information Criteria, BNP B-type natriuretic peptide, CAD coronary artery disease, CI confidence interval, hs-Tnl high-sensitivity troponin I, IDI integrated discrimination improvement, MACE major adverse cardiovascular event, NRI net reclassification index, T2DM type 2 diabetes mellitus