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Table 4 Performance of models predicting MACEs in stable CAD patients

From: High-sensitivity troponin I and B-type natriuretic peptide biomarkers for prediction of cardiovascular events in patients with coronary artery disease with and without diabetes mellitus

Model

Feature

AIC

NRI (95% CI)

P value

IDI (95% CI)

P value

Model 2

Age ≥ 65 years + Male + T2DM + Hypertension

5701.9

–

–

–

–

Model 3

Model 2 + BNP

5678.3

34.5% (23.8–45.1%)

< 0.001

1.2% (0.7–1.7%)

< 0.001

Model 4

Model 2 + hs-Tnl

5664.5

34.9% (24.8–45.0%)

< 0.001

2.4% (1.6–3.2%)

< 0.001

Model 5

Model 2 + hs-Tnl + BNP

5655.5

29.7% (19.2–40.2%)

< 0.001

2.9% (2.1–3.8%)

< 0.001

  1. Model 2: incorporated variables of age ≥ 65 years, male sex, presence of T2DM and hypertension; Model 3: variables in Model 2 and addition of BNP above optimal cutoff; Model 4: variables in Model 2 and addition of hs-Tnl above optimal cutoff; Model 5: variables in Model 2 and addition of hs-Tnl and BNP above cutoffs
  2. AIC Akaike Information Criteria, BNP B-type natriuretic peptide, CAD coronary artery disease, CI confidence interval, hs-Tnl high-sensitivity troponin I, IDI integrated discrimination improvement, MACE major adverse cardiovascular event, NRI net reclassification index, T2DM type 2 diabetes mellitus