Skip to main content

Table 3 Multivariable Cox regression models predicting MACEs in stable CAD patients

From: High-sensitivity troponin I and B-type natriuretic peptide biomarkers for prediction of cardiovascular events in patients with coronary artery disease with and without diabetes mellitus

VariableModel 1Model 2Model 3Model 4Model 5
HR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P value
Age ≥ 65 years2.53 (2.00–3.21)< 0.0012.36 (1.85–2.99)< 0.0012.29 (1.80–2.91)< 0.0012.31 (1.82–2.93)< 0.0012.28 (1.79–2.90)< 0.001
Male  0.83 (0.68–1.03)0.0890.84 (0.68–1.04)0.0980.85 (0.69–1.05)0.140.85 (0.69–1.06)0.15
T2DM1.25 (0.95–1.65)0.111.24 (0.94–1.63)0.131.30 (0.99–1.71)0.0621.28 (0.97–1.69)0.079
Hypertension1.58 (1.00–2.50)0.0511.54 (0.97–2.45)0.0651.57 (0.99–2.49)0.0551.55 (0.98–2.46)0.063
BNP1.66 (1.36–2.02)<0.0011.42 (1.15–1.75)0.001
hs-Tnl1.97 (1.60–2.41)<0.0011.75 (1.41–2.17)< 0.001
  1. BNP and hs-Tnl are at levels above optimal cutoffs
  2. BNP B-type natriuretic peptide, CAD coronary artery disease, CI confidence interval, HR hazard ratio, hs-Tnl high-sensitivity troponin I, MACE major adverse cardiovascular event, T2DM type 2 diabetes mellitus