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Table 3 Multivariable Cox regression models predicting MACEs in stable CAD patients

From: High-sensitivity troponin I and B-type natriuretic peptide biomarkers for prediction of cardiovascular events in patients with coronary artery disease with and without diabetes mellitus

Variable

Model 1

Model 2

Model 3

Model 4

Model 5

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Age ≥ 65 years

2.53 (2.00–3.21)

< 0.001

2.36 (1.85–2.99)

< 0.001

2.29 (1.80–2.91)

< 0.001

2.31 (1.82–2.93)

< 0.001

2.28 (1.79–2.90)

< 0.001

Male

  

0.83 (0.68–1.03)

0.089

0.84 (0.68–1.04)

0.098

0.85 (0.69–1.05)

0.14

0.85 (0.69–1.06)

0.15

T2DM

–

–

1.25 (0.95–1.65)

0.11

1.24 (0.94–1.63)

0.13

1.30 (0.99–1.71)

0.062

1.28 (0.97–1.69)

0.079

Hypertension

–

–

1.58 (1.00–2.50)

0.051

1.54 (0.97–2.45)

0.065

1.57 (0.99–2.49)

0.055

1.55 (0.98–2.46)

0.063

BNP

–

–

–

–

1.66 (1.36–2.02)

<0.001

–

–

1.42 (1.15–1.75)

0.001

hs-Tnl

–

–

–

–

–

–

1.97 (1.60–2.41)

<0.001

1.75 (1.41–2.17)

< 0.001

  1. BNP and hs-Tnl are at levels above optimal cutoffs
  2. BNP B-type natriuretic peptide, CAD coronary artery disease, CI confidence interval, HR hazard ratio, hs-Tnl high-sensitivity troponin I, MACE major adverse cardiovascular event, T2DM type 2 diabetes mellitus