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Table 4 Multivariable analysis of factors associated with in-hospital mortality during admission for infective endocarditis according to T2DM status

From: Infective endocarditis according to type 2 diabetes mellitus status: an observational study in Spain, 2001–2015

 T2DMNo T2DMTotal
OR (95% CI)OR (95% CI)OR (95% CI)
Time period0.8 (0.8–0.9)0.8 (0.8–0.9)0.8 (0.8–0.9)
Female sex1.3 (1.1–1.6)NS1.2 (1.0–1.3)
Agea1.8 (1.6–2.0)1.8 (1.6–2.0)1.8 (1.7–2.0)
Charlson Comorbidity Index1.6 (1.5–1.8)1.6 (1.5–1.8)1.7 (1.5–1.8)
Acute renal disease2.0 (1.6–2.5)1.9 (1.5–2.4)2.0 (1.7–2.3)
Ischemic heart disease1.3 (1.0–1.6)NSNS
COPD0.7 (0.5–0.9)0.7 (0.5–0.9)0.7 (0.6–0.8)
Shock8.6 (6.1–12.1)7.1 (5.0–10.1)7.4 (5.8–9.5)
Dialysis2.5 (1.8–3.5)1.8 (1.3–2.6)2.1 (1.7–2.7)
Pacemaker implantationNS0.4 (0.2–0.8)0.5 (0.3–0.9)
Mechanical ventilation3.3 (2.5–4.4)3.7 (2.8–4.8)3.4 (2.8–4.1)
Staphylococcus aureusNSNS1.2 (1.0–1.5)
Streptococci0.6 (0.5–0.8)0.4 (0.3–0.6)0.5 (0.4–0.6)
EnterococciNS0.6 (0.5–0.9)0.8 (0.6–0.9)
Streptococcus pneumoniaeNSNS0.2 (0.0–1.0)
T2DMNANA1.1 (0.9–1.2)
  1. Only those variables that showed a significant association after multivariable adjustment are showed
  2. T2DM type 2 diabetes mellitus, COPD chronic obstructive pulmonary disease, OR odds ratio obtained using logistic regression models, 95% CI 95% confidence intervals, NS not significant, NA Not applicable
  3. aAge was introduced as a continuous variable with three categories. Additional file 6: Table S5 shows which study variables were associated with the IHM in the bivariate analysis among those with and without T2DM. All those variables significantly associated with IHM were included in the multivariable model. The variables not always significant and included in the multivariable models because they were considered relevant in other investigations were: prosthetic valve carriers, previous mitral valve disease, previous aortic valve disease, COPD, Gram-negative bacilli, Candidiasis/aspergillosis, readmissions, heart valve surgery, Coagulase-negative staphylococci and Streptococcus pneumoniae