Table 4 Multivariable analysis of factors associated with in-hospital mortality during admission for infective endocarditis according to T2DM status

Time period

0.8 (0.8–0.9)

0.8 (0.8–0.9)

0.8 (0.8–0.9)

Female sex

1.3 (1.1–1.6)

NS

1.2 (1.0–1.3)

Age^a

1.8 (1.6–2.0)

1.8 (1.6–2.0)

1.8 (1.7–2.0)

Charlson Comorbidity Index

1.6 (1.5–1.8)

1.6 (1.5–1.8)

1.7 (1.5–1.8)

Acute renal disease

2.0 (1.6–2.5)

1.9 (1.5–2.4)

2.0 (1.7–2.3)

Ischemic heart disease

1.3 (1.0–1.6)

NS

NS

COPD

0.7 (0.5–0.9)

0.7 (0.5–0.9)

0.7 (0.6–0.8)

Shock

8.6 (6.1–12.1)

7.1 (5.0–10.1)

7.4 (5.8–9.5)

Dialysis

2.5 (1.8–3.5)

1.8 (1.3–2.6)

2.1 (1.7–2.7)

Pacemaker implantation

NS

0.4 (0.2–0.8)

0.5 (0.3–0.9)

Mechanical ventilation

3.3 (2.5–4.4)

3.7 (2.8–4.8)

3.4 (2.8–4.1)

Staphylococcus aureus

NS

NS

1.2 (1.0–1.5)

Streptococci

0.6 (0.5–0.8)

0.4 (0.3–0.6)

0.5 (0.4–0.6)

Enterococci

NS

0.6 (0.5–0.9)

0.8 (0.6–0.9)

Streptococcus pneumoniae

NS

NS

0.2 (0.0–1.0)

T2DM

NA

NA

1.1 (0.9–1.2)