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Table 2 Predictors of time to first hHF (SMQ definition)

From: Heart failure with insulin degludec versus glargine U100 in patients with type 2 diabetes at high risk of cardiovascular disease: DEVOTE 14

Baseline predictorHazard ratio [95% CI]Relative importanceP-value
Prior heart failure (Y vs. N)4.89 [3.90; 6.14]54.6< 0.0001
Hepatic impairment (Y vs. N)3.08 [2.15; 4.41]11.0< 0.0001
eGFR (log regression)0.44 [0.34; 0.58]10.0< 0.0001
Atrial fibrillation (Y vs. N)1.95 [1.50; 2.55]7.2< 0.0001
Total insulin dose (U/kg) at week 11.53 [1.27; 1.84]5.9< 0.0001
Prior myocardial infarction (Y vs. N)1.54 [1.23; 1.91]4.30.0001
Macular edema (Y vs. N)3.77 [1.40; 10.2]2.00.0087
A1C (squared regression)1.00 [1.00; 1.01]1.80.0137
Proteinuria (microalbuminuria and gross proteinuria)1.36 [1.06; 1.73]1.80.0140
Systolic blood pressure at baseline1.01 [1.00; 1.01]1.50.0251
  1. Variables identified by stepwise selection − FAS. Relative importance is calculated as 100 × Chi square/Total Chi square, where the Chi squares are from a model simultaneously considering all effects mentioned in the table
  2. A1C glycosylated hemoglobin, CI confidence interval, eGFR estimated glomerular filtration rate, FAS full analysis set, hHF hospitalization for heart failure, N no, SMQ standardized Medical Dictionary for Regulatory Activities Query, U units, Y yes