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Table 3 Univariate and multivariate analysis and predictors of MACCEs within 1 year after PCI

From: High triglyceride–glucose index is associated with poor prognosis in patients with acute ST-elevation myocardial infarction after percutaneous coronary intervention

Variable

Univariate analysis

Multivariate analysis

OR

95% CI

P value

OR

95% CI

P value

TyG index grouping

 Q1

1

  

1

  

 Q2

1.096

0.778–1.545

0.600

1.117

0.668–1.843

0.587

 Q3

1.542

1.083–2.194

0.016

1.356

0.852–2.160

0.199

 Q4

1.809

1.263–2.590

0.001

1.529

1.001–2.061

0.003

Age, years

1.021

1.011–1.032

< 0.001

1.011

0.992–1.031

0.233

Male

0.922

0.676–1.256

0.605

   

BMI, kg/m2

1.005

0.950–1.043

0.460

   

SBP, mmHg

1.001

0.994–1.006

0.839

   

DBP, mmHg

0.990

0.981–0.999

0.029

0.993

0.982–1.005

0.258

Heart rate, bpm

0.999

0.991–1.008

0.905

   

Killip class > 1

2.188

1.667–2.874

< 0.001

1.722

1.185–2.471

0.002

Smoker

1.347

1.047–1.733

0.020

1.191

0.858–1.653

0.297

Hypertension

1.631

1.250–2.127

< 0.001

   

Diabetes mellitus

1.672

1.261–2.216

< 0.001

   

Anemia

1.351

0.940–1.941

< 0.001

1.282

0.995–1.563

0.024

Previous AMI

1.151

0.499–2.655

0.742

   

Atrial fibrillation

0.864

0.463–1.611

0.645

   

Biochemical indicators

 NT-proBNP, pg/mL (IQR)

1.057

0.909–1.158

0.770

   

 Cardiac troponin I, ng/ml

1.018

0.830–1.257

0.571

   

 hs-CRP, mg/L (IQR)

1.026

0.975–1.074

0.302

   

 White blood cells, 109/L

1.037

1.001–1.075

0.047

1.038

0.988–1.091

0.141

 Neutrophil ratio

0.998

0.988–1.008

0.680

   

 Platelet, 109/L

1.002

1.000–1.004

0.025

1.002

0.999–1.004

0.285

 Albumin, g/L

0.971

0.947–0.996

0.023

0.963

0.928–1.000

0.050

 Measured HbA1c,  %

1.173

1.042–1.321

0.005

   

 FPG, mmol/L

1.040

1.010–1.072

0.009

   

 TC, mmol/L

1.015

0.916–1.124

0.781

   

 Triglycerides, mmol/L

1.021

0.909–1.131

0.503

   

 HDL-C, mmol/L

0.813

0.494–1.339

0.813

   

 LDL-C, mmol/L

0.938

0.806–1.092

0.412

   

 Uric acid, umol/L

1.002

1.001–1.003

0.002

1.002

1.000–1.004

0.013

 eGFR, mL/min

0.995

0.991–0.999

0.009

0.999

0.993–1.005

0.751

Coronary angiography

 GPIIb/IIIa antagonists

0.910

0.703–1.176

0.470

   

 Anticoagulation

1.406

0.773–2.557

0.264

   

 Lesion vessels

1.163

1.071–1.263

< 0.001

1.092

0.960–1.243

0.180

 Three-vessel disease

1.394

1.084–1.793

0.010

1.244

0.830–1.865

0.289

 Number of stents

1.575

1.220–2.032

< 0.001

1.709

1.229–2.375

0.001

 Gensini score

1.008

1.002–1.017

0.022

1.002

0.993–1.010

0.366

 LVEF

0.303

0.099–0.931

0.037

0.121

0.029–0.057

0.004

Medications use at discharge

 Aspirin

0.687

0.368–1.282

0.238

   

 Clopidogrel/ticagrelor

0.782

0.276–2.213

0.643

   

 Statin

1.776

0.834–3.781

0.136

   

 Beta blockers

0.979

0.716–1.339

0.895

   

 ACEI/ARB

1.208

0.917–1.590

0.179

   
  1. Co-linearity analysis showed that hypertension, diabetes, HbA1c, FPG and TyG index had high co-linearity. Therefore, hypertension, diabetes, HbA1c and FPG weren’t included in multivariate model
  2. BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, AMI acute myocardial infarction, IQR interquartile range, hs-CRP hypersensitive C-reactive protein, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, SCr Serum creatinine concentration, eGFR estimated glomerular filtration rate, LVEF left ventricular ejection fraction, ACEI angiotensin converting enzyme inhibitor, ARB angiotensin receptor blocker
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Cardiovascular Diabetology

ISSN: 1475-2840