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Table 2 Bio-humoral characteristics of the clinical population

From: Association of PCSK9 plasma levels with metabolic patterns and coronary atherosclerosis in patients with stable angina

  Clinical population n = 539 Quartile I < 138 ng/L n = 135 Quartile II–III 138–264 ng/L n = 270 Quartile IV > 264 ng/L n = 134 P value
Renal
 Creatinine, mg/dL 0.87 ± 0.23 0.91 ± 0.27 0.87 ± 0.22 0.86 ± 0.19 ns
Hepatic
 AST, IU/L 24 ± 10 24 ± 11 24 ± 10 26 ± 9 0.0411
 ALT, IU/L 21 ± 13 19 ± 11 21 ± 14 23 ± 13 0.0180
 ALP, IU/L 51 ± 18 47 ± 17 49 ± 16 61 ± 20 < 0.0001
Metabolic (glucose)
 FTP, mg/dL 112 ± 36 109 ± 30 116 ± 41 109 ± 29 ns
 FTP ≥ 100 mg/dLa 339 (63) 82 (61) 174 (64) 83 (62) ns
 Insulin, μUI/mL 11.6 ± 11.0 13.3 ± 12.5 11.3 ± 10.1 10.3 ± 10.1 0.0345*
 HOMA-IR index 3.5 ± 4.2 3.9 ± 4.5 3.5 ± 4.1 2.9 ± 3.2 0.0569*
Metabolic (lipid)
 Total cholesterol, mg/dL 183 ± 49 171 ± 43 180 ± 45 201 ± 55 < 0.0001
 LDL, mg/dL 106 ± 40 100 ± 37 104 ± 38 118 ± 45 0.0015
 HDL, mg/dL 52 ± 17 46 ± 13 52 ± 15 61 ± 19 < 0.0001
 HDL ≤ 40 mg/dL, male or HDL ≤ 50 mg/dL, femalea 160 (30) 60 (44) 81 (30) 19 (14) < 0.0001
 Total/HDL cholesterol 3.7 ± 1.1 3.8 ± 1.2 3.7 ± 1.2 3.5 ± 1.1 0.0193
 Apo A1, mg/dL 143 ± 32 132 ± 32 143 ± 30 154 ± 34 < 0.0001
 Apo B, mg/dL 87 ± 28 82 ± 28 87 ± 27 93 ± 29 0.0024
 Lipoprotein (a) 21.3 ± 23.2 15.8 ± 18.2 21.7 ± 23.4 24.9 ± 26.3 0.0018
 Triglicerides, mg/dL 124 ± 81 126 ± 84 127 ± 86 118 ± 68 ns
 Triglyceride ≥ 150 mg/dLa 131 (24) 34 (25) 67 (25) 30 (23) ns
Inflammatory and vascular
 hs-CRP, mg/dL 0.40 ± 1.09 0.41 ± 0.61 0.38 ± 1.35 0.43 ± 0.81 ns
 Interleukin 6, ng/L 1.35 ± 2.35 1.56 ± 2.71 1.27 ± 2.45 1.30 ± 1.67 ns
Adipokines
 Adiponectin, μg/mL 9.8 ± 6.9 8.11 ± 5.1 9.98 ± 7.2 11.19 ± 7.6 0.0006
 Leptin, ng/mL 9.93 ± 10.66 11.38 ± 13 9.16 ± 9 9.99 ± 10.98 ns
  1. Continuous variables are presented as mean ± standard deviation
  2. * I vs. IV quartile
  3. aCriteria of metabolic syndrome