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Table 2 Bio-humoral characteristics of the clinical population

From: Association of PCSK9 plasma levels with metabolic patterns and coronary atherosclerosis in patients with stable angina

 

Clinical population

n = 539

Quartile I

< 138 ng/L

n = 135

Quartile II–III

138–264 ng/L

n = 270

Quartile IV

> 264 ng/L

n = 134

P value

Renal

 Creatinine, mg/dL

0.87 ± 0.23

0.91 ± 0.27

0.87 ± 0.22

0.86 ± 0.19

ns

Hepatic

 AST, IU/L

24 ± 10

24 ± 11

24 ± 10

26 ± 9

0.0411

 ALT, IU/L

21 ± 13

19 ± 11

21 ± 14

23 ± 13

0.0180

 ALP, IU/L

51 ± 18

47 ± 17

49 ± 16

61 ± 20

< 0.0001

Metabolic (glucose)

 FTP, mg/dL

112 ± 36

109 ± 30

116 ± 41

109 ± 29

ns

 FTP ≥ 100 mg/dLa

339 (63)

82 (61)

174 (64)

83 (62)

ns

 Insulin, μUI/mL

11.6 ± 11.0

13.3 ± 12.5

11.3 ± 10.1

10.3 ± 10.1

0.0345*

 HOMA-IR index

3.5 ± 4.2

3.9 ± 4.5

3.5 ± 4.1

2.9 ± 3.2

0.0569*

Metabolic (lipid)

 Total cholesterol, mg/dL

183 ± 49

171 ± 43

180 ± 45

201 ± 55

< 0.0001

 LDL, mg/dL

106 ± 40

100 ± 37

104 ± 38

118 ± 45

0.0015

 HDL, mg/dL

52 ± 17

46 ± 13

52 ± 15

61 ± 19

< 0.0001

 HDL ≤ 40 mg/dL, male or HDL ≤ 50 mg/dL, femalea

160 (30)

60 (44)

81 (30)

19 (14)

< 0.0001

 Total/HDL cholesterol

3.7 ± 1.1

3.8 ± 1.2

3.7 ± 1.2

3.5 ± 1.1

0.0193

 Apo A1, mg/dL

143 ± 32

132 ± 32

143 ± 30

154 ± 34

< 0.0001

 Apo B, mg/dL

87 ± 28

82 ± 28

87 ± 27

93 ± 29

0.0024

 Lipoprotein (a)

21.3 ± 23.2

15.8 ± 18.2

21.7 ± 23.4

24.9 ± 26.3

0.0018

 Triglicerides, mg/dL

124 ± 81

126 ± 84

127 ± 86

118 ± 68

ns

 Triglyceride ≥ 150 mg/dLa

131 (24)

34 (25)

67 (25)

30 (23)

ns

Inflammatory and vascular

 hs-CRP, mg/dL

0.40 ± 1.09

0.41 ± 0.61

0.38 ± 1.35

0.43 ± 0.81

ns

 Interleukin 6, ng/L

1.35 ± 2.35

1.56 ± 2.71

1.27 ± 2.45

1.30 ± 1.67

ns

Adipokines

 Adiponectin, μg/mL

9.8 ± 6.9

8.11 ± 5.1

9.98 ± 7.2

11.19 ± 7.6

0.0006

 Leptin, ng/mL

9.93 ± 10.66

11.38 ± 13

9.16 ± 9

9.99 ± 10.98

ns

  1. Continuous variables are presented as mean ± standard deviation
  2. * I vs. IV quartile
  3. aCriteria of metabolic syndrome