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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Luseogliflozin attenuates neointimal hyperplasia after wire injury in high-fat diet-fed mice via inhibition of perivascular adipose tissue remodeling

Fig. 1

Effects of luseogliflozin and PVAT removal on vascular injury in HFD- or LFD-fed mice. HFD- or LFD-fed mice were treated with vehicle or luseogliflozin, and underwent bilateral femoral artery wire injury followed by unilateral PVAT removal. Femoral arteries were evaluated at 25 days after vascular injury. a, e Representative microscopic images of Elastica van Gieson-stained cross-sections of femoral arteries of mice fed with HFD (a) or LFD (e). Arrows indicate the neointima. Scale bar = 200 μm. b, f Neointimal area. c, g Medial area. d, h I/M ratio. bd HFD and vehicle, N = 12; HFD and Luseogliflozin (Luseo), N = 8. fh LFD and vehicle, N = 5; LFD and Luseo, N = 5. *p < 0.05, **p < 0.01

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