Fatty acids | Placebo | Liraglutide | P1 | P2 | P3 | P4 | ||||
---|---|---|---|---|---|---|---|---|---|---|
Visit 1 | Visit 6 | Delta changes | Visit 1 | Visit 6 | Delta changes | |||||
TotFA | 9.04 ± 2.01 | 9.47 ± 2.1 | 0.44 ± 0.25 | 8.65 ± 1.94 | 8.5 ± 1.9 | − 0.16 ± 0.2 | 0.07 | 0.07 | ||
UnSat (× 102) | 110 ± 24.6 | 112 ± 25 | 1.73 ± 0.84 | 110 ± 24.7 | 112 ± 25 | 1.22 ± 0.91 | 0.64 | 0.74 | ||
DHA (× 102) | 8.7 ± 1.93 | 10 ± 2.21 | 1.75 ± 0.85 | 9.07 ± 2.03 | 8.77 ± 1.96 | − 0.3 ± 0.46 | 0.04 | 0.09 | ||
LA | 2.5 ± 0.55 | 2.65 ± 0.59 | 0.15 ± 0.06 | 2.39 ± 0.54 | 2.38 ± 0.53 | − 0.02 ± 0.08 | 0.07 | 0.1 | ||
FAw3 | 0.28 ± 0.06 | 0.31 ± 0.07 | 0.04 ± 0.01 | 0.27 ± 0.06 | 0.27 ± 0.06 | 0.002 ± 0.02 | 0.04 | 0.11 | ||
FAw6 | 3.02 ± 0.67 | 3.18 ± 0.71 | 0.16 ± 0.07 | 2.92 ± 0.65 | 2.87 ± 0.64 | − 0.05 ± 0.08 | 0.03 | 0.04 | ||
PUFA | 3.3 ± 0.73 | 3.5 ± 0.78 | 0.2 ± 0.08 | 3.19 ± 0.71 | 3.14 ± 0.7 | − 0.05 ± 0.1 | 0.03 | 0.05 | ||
MUFA | 2.27 ± 0.51 | 2.36 ± 0.52 | 0.09 ± 0.08 | 2.21 ± 0.49 | 2.17 ± 0.49 | − 0.04 ± 0.06 | 0.23 | 0.15 | ||
SFA | 3.41 ± 0.76 | 3.53 ± 0.78 | 0.12 ± 0.1 | 3.25 ± 0.73 | 3.18 ± 0.71 | − 0.07 ± 0.06 | 0.12 | 0.1 | ||
C22:0 | 0.15 ± 0.01 | 0.14 ± 0.01 | − 0.01 ± 0.01 | 0.14 ± 0.01 | 0.17 ± 0.01 | 0.02 ± 0.01 | 0.02 | 0.03 | ||
Amino acids | ||||||||||
Tyrosine (× 102) | 6.15 ± 1.38 | 6.46 ± 1.44 | 0.31 ± 0.26 | 6.48 ± 1.45 | 5.77 ± 1.29 | − 0.71 ± 0.25 | 0.03 | 0.001 | ||
ELISAs | ||||||||||
Follistatin | 3.43 ± 0.26 | 3.62 ± 0.25 | 0.01 ± 0.16 | 3.51 ± 0.32 | 2.7 ± 0.26 | − 0.95 ± 0.24 | 0.007 | 0.004 | 0.02 | 0.81 |
FSTL3 | 12.5 ± 0.65 | 12.1 ± 0.48 | − 1.03 ± 0.52 | 12.5 ± 0.68 | 12 ± 0.77 | − 0.52 ± 0.6 | 0.52 | 0.31 | 0.67 | 0.88 |
Activin A | 0.43 ± 0.02 | 0.37 ± 0.03 | − 0.08 ± 0.02 | 0.43 ± 0.03 | 0.3 ± 0.02 | − 0.12 ± 0.02 | 0.13 | 0.85 | 0.17 | 0.9 |
Activin B | 96.6 ± 8.71 | 101 ± 8.5 | 4.51 ± 4.59 | 99.2 ± 10.2 | 109 ± 10.7 | 4.66 ± 3.27 | 0.98 | 0.95 | 0.72 | 0.65 |
Activin AB | 3.26 ± 0.38 | 3.76 ± 0.41 | 0.52 ± 0.2 | 3.57 ± 0.46 | 2.94 ± 0.42 | − 0.63 ± 0.29 | 0.04 | 0.004 | 0.03 | 0.1 |
Activin A/FST | 0.14 ± 0.01 | 0.11 ± 0.01 | − 0.03 ± 0.01 | 0.14 ± 0.01 | 0.13 ± 0.01 | − 0.01 ± 0.01 | 0.26 | 0.03 | 0.33 | 0.52 |
Activin B/FST | 31.6 ± 3.57 | 30.8 ± 3.33 | − 1.01 ± 2.03 | 30.5 ± 2.79 | 41.8 ± 4.31 | 10.3 ± 2.45 | 0.01 | 0.03 | 0.02 | 0.09 |
ActivinAB/FST | 1.21 ± 0.2 | 1.18 ± 0.15 | − 0.03 ± 0.09 | 1.16 ± 0.17 | 1.24 ± 0.21 | 0.08 ± 0.13 | 0.43 | 0.54 | 0.46 | 0.13 |