Table 4 Hazard ratios and 95% confidence intervals of myocardial infarction and stroke by low-density lipoprotein cholesterol (LDL-C) category; Sensitivity analysis excluding subjects with the occurrence of end points within 2 year of follow-up
| Â | Total | Statin non-user | Statin user | ||||||
|---|---|---|---|---|---|---|---|---|---|
Events (n) | Incidence rate (per 1000 person-years) | HR (95% CI)* | Events (n) | Incidence rate (per 1000 person-years) | HR (95% CI)* | Events (n) | Incidence rate (per 1000 person-years) | HR (95% CI)* | |
MI | |||||||||
 < 70 | 4058 | 3.78 | 1 (ref.) | 1788 | 3.77 | 1 (ref.) | 2270 | 3.79 | 1 (ref.) |
 70–99 | 9274 | 3.65 | 1.00 (0.96, 1.03) | 5467 | 3.49 | 0.94 (0.90, 1.00) | 3807 | 3.90 | 1.05 (1.00, 1.11) |
 100–129 | 11,518 | 3.74 | 1.07 (1.03, 1.11) | 8591 | 3.62 | 1.02 (0.97, 1.07) | 2927 | 4.12 | 1.15 (1.09, 1.21) |
 130–159 | 8182 | 4.10 | 1.22 (1.18, 1.27) | 6209 | 4.06 | 1.20 (1.13, 1.26) | 1973 | 4.20 | 1.21 (1.14, 1.29) |
 ≥ 160 | 4887 | 4.63 | 1.44 (1.38, 1.50) | 3148 | 4.80 | 1.48 (1.40, 1.57) | 1739 | 4.36 | 1.32 (1.24, 1.41) |
P for trend |  |  | < 0.0001 |  |  | < 0.0001 |  |  | < 0.0001 |
Stroke | |||||||||
 < 70 | 6434 | 6.03 | 1 (ref.) | 3083 | 6.54 | 1 (ref.) | 3351 | 5.62 | 1 (ref.) |
 70–99 | 14,892 | 5.89 | 1.00 (0.97, 1.03) | 9410 | 6.04 | 0.96 (0.92, 1.01) | 5482 | 5.64 | 1.03 (0.99, 1.08) |
 100–129 | 18,137 | 5.91 | 1.04 (1.01, 1.07) | 14,011 | 5.94 | 0.99 (0.95, 1.03) | 4126 | 5.83 | 1.11 (1.06, 1.16) |
 130–159 | 11,707 | 5.89 | 1.08 (1.05, 1.12) | 9052 | 5.95 | 1.05 (1.01, 1.09) | 2655 | 5.68 | 1.12 (1.07, 1.18) |
 ≥ 160 | 6280 | 5.97 | 1.17 (1.13, 1.21) | 4070 | 6.22 | 1.15 (1.09, 1.20) | 2210 | 5.56 | 1.16 (1.11, 1.23) |
P for trend |  |  | < 0.0001 |  |  | < 0.0001 |  |  | < 0.0001 |