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Table 4 Hazard ratios and 95% confidence intervals of myocardial infarction and stroke by low-density lipoprotein cholesterol (LDL-C) category; Sensitivity analysis excluding subjects with the occurrence of end points within 2 year of follow-up

From: Cholesterol levels and development of cardiovascular disease in Koreans with type 2 diabetes mellitus and without pre-existing cardiovascular disease

  Total Statin non-user Statin user
Events (n) Incidence rate (per 1000 person-years) HR (95% CI)* Events (n) Incidence rate (per 1000 person-years) HR (95% CI)* Events (n) Incidence rate (per 1000 person-years) HR (95% CI)*
MI
 < 70 4058 3.78 1 (ref.) 1788 3.77 1 (ref.) 2270 3.79 1 (ref.)
 70–99 9274 3.65 1.00 (0.96, 1.03) 5467 3.49 0.94 (0.90, 1.00) 3807 3.90 1.05 (1.00, 1.11)
 100–129 11,518 3.74 1.07 (1.03, 1.11) 8591 3.62 1.02 (0.97, 1.07) 2927 4.12 1.15 (1.09, 1.21)
 130–159 8182 4.10 1.22 (1.18, 1.27) 6209 4.06 1.20 (1.13, 1.26) 1973 4.20 1.21 (1.14, 1.29)
 ≥ 160 4887 4.63 1.44 (1.38, 1.50) 3148 4.80 1.48 (1.40, 1.57) 1739 4.36 1.32 (1.24, 1.41)
P for trend    < 0.0001    < 0.0001    < 0.0001
Stroke
 < 70 6434 6.03 1 (ref.) 3083 6.54 1 (ref.) 3351 5.62 1 (ref.)
 70–99 14,892 5.89 1.00 (0.97, 1.03) 9410 6.04 0.96 (0.92, 1.01) 5482 5.64 1.03 (0.99, 1.08)
 100–129 18,137 5.91 1.04 (1.01, 1.07) 14,011 5.94 0.99 (0.95, 1.03) 4126 5.83 1.11 (1.06, 1.16)
 130–159 11,707 5.89 1.08 (1.05, 1.12) 9052 5.95 1.05 (1.01, 1.09) 2655 5.68 1.12 (1.07, 1.18)
 ≥ 160 6280 5.97 1.17 (1.13, 1.21) 4070 6.22 1.15 (1.09, 1.20) 2210 5.56 1.16 (1.11, 1.23)
P for trend    < 0.0001    < 0.0001    < 0.0001
  1. HR, hazard ratio; CI, confidence interval
  2. * Adjusted for age, sex, BMI, smoking, alcohol drinking, exercise, income status, use of statins, fasting glucose levels, hypertension, and duration of diabetes