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Table 3 Risk of myocardial infarction and stroke in patients with type 2 diabetes mellitus according to non-high-density lipoprotein cholesterol (non-HDL-C) category

From: Cholesterol levels and development of cardiovascular disease in Koreans with type 2 diabetes mellitus and without pre-existing cardiovascular disease

  Total Statin non-user Statin user
Events (n) Incidence rate (per 1000 person-years) HR (95% CI)* Events (n) Incidence rate (per 1000 person-years) HR (95% CI)* Events (n) Incidence rate (per 1000 person-years) HR (95% CI)*
Myocardial infarction
 < 100 5609 3.37 1 (ref.) 2521 3.38 1 (ref.) 3088 3.36 1 (ref.)
 100–129 11,540 3.35 1.07 (1.03, 1.10) 6898 3.13 0.97 (0.92, 1.0) 4642 3.76 1.16 (1.11, 1.21)
 130–159 14,768 3.51 1.19 (1.15, 1.23) 10,638 3.30 1.07 (1.02, 1.12) 4130 4.18 1.33 (1.27, 1.40)
 160–189 11,614 3.87 1.38 (1.34, 1.43) 8248 3.66 1.26 (1.20, 1.31) 3366 4.49 1.49 (1.42, 1.57)
 ≥ 190 9158 4.57 1.69 (1.63, 1.75) 5607 4.50 1.64 (1.57, 1.72) 3551 4.68 1.63 (1.55, 1.71)
P for trend    < 0.0001    < 0.0001    < 0.0001
Stroke
 < 100 9171 5.55 1 (ref.) 4514 6.10 1 (ref.) 4657 5.10 1 (ref.)
 100–129 18,768 5.49 1.05 (1.02, 1.07) 12,045 5.50 0.96 (0.92, 0.99) 6723 5.47 1.13 (1.08, 1.17)
 130–159 23,725 5.68 1.15 (1.12, 1.17) 17,766 5.56 1.03 (0.99, 1.06) 5959 6.07 1.30 (1.25, 1.35)
 160–189 17,435 5.85 1.25 (1.22, 1.29) 12,748 5.70 1.12 (1.08, 1.16) 4687 6.30 1.42 (1.36, 1.48)
 ≥ 190 12,194 6.11 1.39 (1.35, 1.43) 7563 6.10 1.29 (1.24, 1.34) 4631 6.14 1.45 (1.39, 1.52)
P for trend    < 0.0001    < 0.0001    < 0.0001
  1. HR, hazard ratio; CI, confidence interval
  2. * Adjusted for age, sex, BMI, smoking, alcohol drinking, exercise, income status, use of statins, fasting glucose levels, hypertension, and duration of diabetes