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Table 2 Risk of myocardial infarction and stroke in patients with type 2 diabetes mellitus according to low-density lipoprotein cholesterol (LDL-C) category

From: Cholesterol levels and development of cardiovascular disease in Koreans with type 2 diabetes mellitus and without pre-existing cardiovascular disease

  Total Statin non-user Statin user
Events (n) Incidence rate (per 1000 person-years) HR (95% CI)* Events (n) Incidence rate (per 1000 person-years) HR (95% CI)* Events (n) Incidence rate (per 1000 person-years) HR (95% CI)*
Myocardial infarction
 < 70 5342 3.50 1 (ref.) 2330 3.44 1 (ref.) 3012 3.55 1 (ref.)
 70–99 12,274 3.41 1.02 (0.99, 1.06) 7152 3.22 0.95 (0.91, 1.00) 5122 3.71 1.07 (1.03, 1.12)
 100–129 15,366 3.52 1.12 (1.09, 1.16) 11,122 3.31 1.02 (0.97, 1.07) 4244 4.22 1.26 (1.20, 1.32)
 130–159 10,981 3.88 1.29 (1.25, 1.34) 7985 3.69 1.19 (1.14, 1.25) 2996 4.51 1.39 (1.32, 1.46)
 ≥ 160 6828 4.56 1.56 (1.51, 1.62) 4228 4.53 1.53 (1.46, 1.62) 2600 4.60 1.49 (1.41, 1.57)
 P for trend    < 0.0001    < 0.0001    < 0.0001
Stroke
 < 70 8527 5.63 1 (ref.) 4077 6.07 1 (ref.) 4450 5.27 1 (ref.)
 70–99 19,873 5.56 1.03 (1.00, 1.05) 12,387 5.62 0.96 (0.93, 1.00) 7486 5.46 1.07 (1.03, 1.11)
 100–129 24,759 5.72 1.11 (1.08, 1.14) 18,611 5.59 1.01 (0.97, 1.04) 6148 6.16 1.25 (1.20, 1.30)
 130–159 16,354 5.82 1.19 (1.15, 1.22) 12,211 5.68 1.08 (1.04, 1.12) 4143 6.27 1.31 (1.26, 1.37)
 ≥ 160 9047 6.07 1.30 (1.26, 1.34) 5655 6.09 1.21 (1.17, 1.26) 3392 6.04 1.33 (1.27, 1.40)
 P for trend    < 0.0001    < 0.0001    < 0.0001
  1. HR, hazard ratio; CI, confidence interval
  2. * Adjusted for age, sex, BMI, smoking, alcohol drinking, exercise, income status, use of statins, fasting glucose levels, hypertension, and duration of diabetes