Skip to main content

Table 2 Risk of myocardial infarction and stroke in patients with type 2 diabetes mellitus according to low-density lipoprotein cholesterol (LDL-C) category

From: Cholesterol levels and development of cardiovascular disease in Koreans with type 2 diabetes mellitus and without pre-existing cardiovascular disease

 

Total

Statin non-user

Statin user

Events (n)

Incidence rate (per 1000 person-years)

HR (95% CI)*

Events (n)

Incidence rate (per 1000 person-years)

HR (95% CI)*

Events (n)

Incidence rate (per 1000 person-years)

HR (95% CI)*

Myocardial infarction

 < 70

5342

3.50

1 (ref.)

2330

3.44

1 (ref.)

3012

3.55

1 (ref.)

 70–99

12,274

3.41

1.02 (0.99, 1.06)

7152

3.22

0.95 (0.91, 1.00)

5122

3.71

1.07 (1.03, 1.12)

 100–129

15,366

3.52

1.12 (1.09, 1.16)

11,122

3.31

1.02 (0.97, 1.07)

4244

4.22

1.26 (1.20, 1.32)

 130–159

10,981

3.88

1.29 (1.25, 1.34)

7985

3.69

1.19 (1.14, 1.25)

2996

4.51

1.39 (1.32, 1.46)

 ≥ 160

6828

4.56

1.56 (1.51, 1.62)

4228

4.53

1.53 (1.46, 1.62)

2600

4.60

1.49 (1.41, 1.57)

 P for trend

  

< 0.0001

  

< 0.0001

  

< 0.0001

Stroke

 < 70

8527

5.63

1 (ref.)

4077

6.07

1 (ref.)

4450

5.27

1 (ref.)

 70–99

19,873

5.56

1.03 (1.00, 1.05)

12,387

5.62

0.96 (0.93, 1.00)

7486

5.46

1.07 (1.03, 1.11)

 100–129

24,759

5.72

1.11 (1.08, 1.14)

18,611

5.59

1.01 (0.97, 1.04)

6148

6.16

1.25 (1.20, 1.30)

 130–159

16,354

5.82

1.19 (1.15, 1.22)

12,211

5.68

1.08 (1.04, 1.12)

4143

6.27

1.31 (1.26, 1.37)

 ≥ 160

9047

6.07

1.30 (1.26, 1.34)

5655

6.09

1.21 (1.17, 1.26)

3392

6.04

1.33 (1.27, 1.40)

 P for trend

  

< 0.0001

  

< 0.0001

  

< 0.0001

  1. HR, hazard ratio; CI, confidence interval
  2. * Adjusted for age, sex, BMI, smoking, alcohol drinking, exercise, income status, use of statins, fasting glucose levels, hypertension, and duration of diabetes