Previous knowledge in the field |
Multiple GLP-1 RA and SGLT2i demonstrated benefit on cardiovascular outcomes, mortality, and/or renal disease progression |
The mechanisms underlying these effects, while not fully understood, are largely distinct |
Combination GLP-1 RA and SGLT2i treatment improves metabolic parameters and cardiovascular risk factors, but no data on cardiovascular events, mortality, or renal function decline is available |
New insights from this study |
Combination exenatide QW and SGLT2i numerically lowered the hazard ratio for MACE, driven by a significant reduction in cardiovascular death compared to exenatide alone or neither drug class |
All-cause mortality risk decreased with the combination, compared to exenatide QW alone or placebo |
SGLT2i-mediated eGFR slope improvement was consistent on top of placebo or exenatide QW treatment |
This data supports the hypothesis that combination GLP-1 RA and SGLT2i may provide additional cardiovascular and mortality benefit to GLP-1 RA alone, without any increase in risk of hypoglycemia |