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Table 6 Sensitivity and specificity of candidate biomarkers for GDM

From: Predictive and diagnostic biomarkers for gestational diabetes and its associated metabolic and cardiovascular diseases

Biomarker

Week of pregnancy

Sensitivity (%)

Specificity (%)

References

SHGB

1st–12th

85.0

55.3

[121, 145]

hs-CRP

4–6th

89.0

55.3

[121]

11–14th

86.2

50.8

[122]

FGF-21

24–28th

100.0

75.0

[148]

miR-16-5p

4–6th

41.6

95.8

[159]

miR-17-5p

4–6th

21.4

95.4

miR-20a-5p

4–6th

17.8

95.4

FABP4

4–6th

81.8

71.2

[133]

23rd–30th

87.0

89.0

[135]

Adiponectin

16–18th

80.7

65.1

[117]

24–28th

83.6

56.6

[113]

RBP4

16–18th

79.4

79.1

[136]

63.6

75.0

[117]

Leptin

24–28th

81.2

64.2

[113]

miR-132

16th

66.7

63.3

[154]

miR-29a

miR-222

Ficolin-3

16–18th

51.1

97.7

[117]

Fetuin-A

11–14th

58.6

76.2

[122]

miR-21-3p

30–36th

52.6

89.3

[165]

  1. Some of the predictive or diagnostic biomarkers (protein and miR) for GDM were analysed for sensitivity and specificity unveiling different data. These parameters, together with reproducibility and accuracy in quantification will be crucial to validate biomarkers for clinical practise