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Table 6 Sensitivity and specificity of candidate biomarkers for GDM

From: Predictive and diagnostic biomarkers for gestational diabetes and its associated metabolic and cardiovascular diseases

Biomarker Week of pregnancy Sensitivity (%) Specificity (%) References
SHGB 1st–12th 85.0 55.3 [121, 145]
hs-CRP 4–6th 89.0 55.3 [121]
11–14th 86.2 50.8 [122]
FGF-21 24–28th 100.0 75.0 [148]
miR-16-5p 4–6th 41.6 95.8 [159]
miR-17-5p 4–6th 21.4 95.4
miR-20a-5p 4–6th 17.8 95.4
FABP4 4–6th 81.8 71.2 [133]
23rd–30th 87.0 89.0 [135]
Adiponectin 16–18th 80.7 65.1 [117]
24–28th 83.6 56.6 [113]
RBP4 16–18th 79.4 79.1 [136]
63.6 75.0 [117]
Leptin 24–28th 81.2 64.2 [113]
miR-132 16th 66.7 63.3 [154]
miR-29a
miR-222
Ficolin-3 16–18th 51.1 97.7 [117]
Fetuin-A 11–14th 58.6 76.2 [122]
miR-21-3p 30–36th 52.6 89.3 [165]
  1. Some of the predictive or diagnostic biomarkers (protein and miR) for GDM were analysed for sensitivity and specificity unveiling different data. These parameters, together with reproducibility and accuracy in quantification will be crucial to validate biomarkers for clinical practise