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Table 1 Current criteria for GDM prediction

From: Predictive and diagnostic biomarkers for gestational diabetes and its associated metabolic and cardiovascular diseases

Association

Screening type

Screening approach (first pre-natal visit)

Cut-offs for GDM prediction

IADPSG

Universal

Fasting plasma glucose test

Fasting glycemia ≥ 92 mg/dL (5.1 mM) predict GDMd

DGGG

High risk womena

Random plasma glucose test

Glucose ≥ 200 mg/dL (11.1 mM) proceed with fasting plasma glucose test

Glucose 140–199 mg/dL (7.8–11.0 mM) proceed with fasting plasma glucose test or OGTT

NICE

Women with previous GDM

One-step strategy (2 h OGTT for 75 g glucose overload)

Fasting glycemia ≥ 100.8 mg/dL (5.6 mM)

Glycemia 2 h after overload ≥ 140.4 mg/dL (7.8 mM)

NIH

High risk womenb

Two-steps strategy (1 h GCT for 50 g glucose overload + 3 h 100 g glucose overload)

Step 1: If glycemia ≥ 130 mg/dL (7.2 mM), proceed with

Step 2e:

Fasting glycemia ≥ 95 mg/dL (5.3 mM)

Glycemia 1 h after overload ≥ 180 mg/dL (10.0 mM)

Glycemia 2 h after overload ≥ 155 mg/dL (8.6 mM)

Glycemia 3 h after overload ≥ 140 mg/dL (7.8 mM)

JOGC

High risk womenc

Two-steps strategy (1 h GCT for 50 g glucose overload + 2 h OGTT for 75 g glucose overload)

Step 1: If glycemia ≥ 200 mg/dL (11.1 mM), GDM is diagnosed

If glycemia ≥ 140–200 mg/dL (7.8–11.1 mM), proceed with

Step 2:

Fasting glycemia ≥ 95 mg/dL (5.3 mM)

Glycemia 1 h after overload ≥ 190 mg/dL (10.6 mM)

Glycemia 2 h after overload ≥ 162 mg/dL (9.0 mM)

  1. After universal or selective screening of pregnant women at the first pre-natal visit, diabetic and obstetrician associations preferentially recommend specific strategies for GDM prediction. Basing on glucose homeostasis, different approaches can be followed. The estimation of GDM is made when any or two (in the 3 h OGTT) cut-offs are met
  2. OGTT oral glucose tolerance test, GCT glucose challenge test
  3. aAge ≥ 45 years-old, pre-gestational BMI ≥ 30 kg/m2, familiar or previous GDM, DM or macrosomia, Asian and Latin American ethnicities, arterial hypertension, dyslipidemia, polycystic ovary syndrome, and history of coronary or cerebral vascular disease
  4. bSimilar to DGGG, but including age ≥ 25 years-old, persistent glucosuria, history of spontaneous abortions and unexplained stillbirths
  5. cSimilar to DGGG, but including age ≥ 35 years-old, and aboriginal and African ethnicities
  6. dIf fasting glycemia ≥ 126 mg/dL (7.0 mmol/L), DM should be considered
  7. eFollowing Carpenter/Coustan conversion method