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Table 1 Current criteria for GDM prediction

From: Predictive and diagnostic biomarkers for gestational diabetes and its associated metabolic and cardiovascular diseases

Association Screening type Screening approach (first pre-natal visit) Cut-offs for GDM prediction
IADPSG Universal Fasting plasma glucose test Fasting glycemia ≥ 92 mg/dL (5.1 mM) predict GDMd
DGGG High risk womena Random plasma glucose test Glucose ≥ 200 mg/dL (11.1 mM) proceed with fasting plasma glucose test Glucose 140–199 mg/dL (7.8–11.0 mM) proceed with fasting plasma glucose test or OGTT
NICE Women with previous GDM One-step strategy (2 h OGTT for 75 g glucose overload) Fasting glycemia ≥ 100.8 mg/dL (5.6 mM) Glycemia 2 h after overload ≥ 140.4 mg/dL (7.8 mM)
NIH High risk womenb Two-steps strategy (1 h GCT for 50 g glucose overload + 3 h 100 g glucose overload) Step 1: If glycemia ≥ 130 mg/dL (7.2 mM), proceed with Step 2e: Fasting glycemia ≥ 95 mg/dL (5.3 mM) Glycemia 1 h after overload ≥ 180 mg/dL (10.0 mM) Glycemia 2 h after overload ≥ 155 mg/dL (8.6 mM) Glycemia 3 h after overload ≥ 140 mg/dL (7.8 mM)
JOGC High risk womenc Two-steps strategy (1 h GCT for 50 g glucose overload + 2 h OGTT for 75 g glucose overload) Step 1: If glycemia ≥ 200 mg/dL (11.1 mM), GDM is diagnosed If glycemia ≥ 140–200 mg/dL (7.8–11.1 mM), proceed with Step 2: Fasting glycemia ≥ 95 mg/dL (5.3 mM) Glycemia 1 h after overload ≥ 190 mg/dL (10.6 mM) Glycemia 2 h after overload ≥ 162 mg/dL (9.0 mM)
  1. After universal or selective screening of pregnant women at the first pre-natal visit, diabetic and obstetrician associations preferentially recommend specific strategies for GDM prediction. Basing on glucose homeostasis, different approaches can be followed. The estimation of GDM is made when any or two (in the 3 h OGTT) cut-offs are met
  2. OGTT oral glucose tolerance test, GCT glucose challenge test
  3. aAge ≥ 45 years-old, pre-gestational BMI ≥ 30 kg/m2, familiar or previous GDM, DM or macrosomia, Asian and Latin American ethnicities, arterial hypertension, dyslipidemia, polycystic ovary syndrome, and history of coronary or cerebral vascular disease
  4. bSimilar to DGGG, but including age ≥ 25 years-old, persistent glucosuria, history of spontaneous abortions and unexplained stillbirths
  5. cSimilar to DGGG, but including age ≥ 35 years-old, and aboriginal and African ethnicities
  6. dIf fasting glycemia ≥ 126 mg/dL (7.0 mmol/L), DM should be considered
  7. eFollowing Carpenter/Coustan conversion method