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Table 2 Impact of body weight status and diabetes on new-onset atrial fibrillation

From: The impact of body weight and diabetes on new-onset atrial fibrillation: a nationwide population based study

 

n

Event

Patient*years

Incidence

Model 1 (95% CI)

Model 2 (95% CI)

Model 3 (95% CI)

Total

 BMI

  < 18.5

374,501

5565

3,019,377

1.843

1.020 (0.993–1.049)

1.055 (1.026–1.085)

1.053 (1.025–1.083)

  18.5–23

3,867,084

62,946

31,641,170

1.989

1 (reference)

1 (reference)

1 (reference)

  23–25

2,423,219

50,163

19,850,785

2.527

1.125 (1.112–1.138)

1.040 (1.028–1.052)

1.042 (1.030–1.055)

  25–30

2,795,090

68,242

22,864,770

2.985

1.290 (1.276–1.304)

1.123 (1.111–1.136)

1.128 (1.115–1.140)

  30–

337,524

9220

2,754,059

3.348

1.606 (1.572–1.642)

1.327 (1.298–1.357)

1.325 (1.296–1.354)

 WC (M/F)

  < 80/75

3,621,432

44,263

29,751,411

1.488

0.726 (0.717–0.736)

0.829 (0.818–0.840)

0.836 (0.825–0.848)

  − 85/80

2,327,214

43,245

19,058,845

2.269

0.870 (0.859–0.882)

0.921 (0.909–0.934)

0.927 (0.915–0.939)

  − 90/85

1,936,668

46,009

15,812,732

2.910

1 (reference)

1 (reference)

1 (reference)

  − 95/90

1,134,028

33,661

9,219,448

3.651

1.148 (1.132–1.164)

1.096 (1.080–1.111)

1.092 (1.076–1.107)

  − 100/95

504,432

17,713

4,085,267

4.336

1.252 (1.230–1.274)

1.176 (1.155–1.196)

1.162 (1.142–1.183)

  ≥ 100/95

273,644

11,245

2,202,458

5.106

1.615 (1.582–1.649)

1.410 (1.381–1.440)

1.369 (1.341–1.398)

Non-diabetic + IFG

 BMI

  < 18.5

361,941

5055

2,931,149

1.725

1.034 (1.004–1.064)

1.056 (1.025–1.087)

1.058 (1.028–1.089)

  18.5–23

3,653,082

54,833

29,975,508

1.829

1 (reference)

1 (reference)

1 (reference)

  23–25

2,206,558

41,998

18,127,691

2.317

1.129 (1.114–1.143)

1.050 (1.036–1.063)

1.049 (1.036–1.062)

  25–30

2,453,625

54,545

20,131,059

2.709

1.288 (1.273–1.303)

1.134 (1.120–1.148)

1.133 (1.119–1.147)

  30–

279,364

6663

2,287,495

2.913

1.541 (1.502–1.581)

1.309 (1.275–1.343)

1.294 (1.261–1.327)

 WC (M/F)

  < 80/75

3,490,482

40,229

28,724,841

1.401

0.727 (0.717–0.737)

0.820 (0.808–0.832)

0.833 (0.821–0.845)

  − 85/80

2,148,892

37,280

17,642,987

2.113

0.872 (0.859–0.884)

0.918 (0.905–0.931)

0.926 (0.913–0.940)

  − 90/85

1,722,709

37,924

14,109,867

2.688

1 (reference)

1 (reference)

1 (reference)

  − 95/90

968,520

26,661

7,904,775

3.373

1.154 (1.136–1.172)

1.107 (1.089–1.124)

1.101 (1.083–1.118)

  − 100/95

412,804

13,266

3,359,409

3.949

1.244 (1.219–1.269)

1.185 (1.161–1.208)

1.163 (1.140–1.186)

  ≥ 100/95

211,163

7734

1,711,022

4.520

1.594 (1.556 –1.634)

1.418 (1.384–1.454)

1.365 (1.332–1.399)

Diabetic

 BMI

  < 18.5

12,560

510

88,228

5.780

1.096 (1.002–1.198)

1.119 (1.024–1.224)

1.100 (1.006–1.203)

  18.5–23

214,002

8113

1,665,662

4.871

1 (reference)

1 (reference)

1 (reference)

  23–25

216,661

8165

1,723,094

4.739

0.993 (0.963–1.024)

0.970 (0.940–1.000)

0.972 (0.942–1.002)

  25–30

341,465

13,697

2,733,711

5.010

1.104 (1.074–1.134)

1.053 (1.024–1.082)

1.054 (1.025–1.084)

  30–

58,160

2557

466,564

5.480

1.486 (1.421–1.554)

1.362 (1.301–1.425)

1.341 (1.282–1.403)

 WC (M/F)

  < 80/75

130,950

4034

1,026,570

3.930

0.920 (0.886–0.955)

0.963 (0.927–1.001)

0.965 (0.929–1.003)

  − 85/80

178,322

5965

1,415,858

4.213

0.925 (0.895–0.957)

0.945 (0.914–0.977)

0.949 (0.917–0.981)

  − 90/85

213,959

8085

1,702,865

4.748

1 (reference)

1 (reference)

1 (reference)

  − 95/90

165,508

7000

1,314,673

5.325

1.084 (1.050–1.119)

1.062 (1.029–1.097)

1.054 (1.021–1.089)

  − 100/95

91,628

4447

725,857

6.127

1.187 (1.144–1.232)

1.156 (1.114–1.200)

1.150 (1.108–1.193)

  ≥ 100/95

62,481

3511

491,435

7.144

1.503 (1.445–1.565)

1.419 (1.363–1.477)

1.371 (1.317–1.427)

  1. Model 1: adjusted for age and sex
  2. Model 2: adjusted for model 1 plus smoking, alcohol consumption, regular physical activity, social income, diabetes, hypertension, and dyslipidemia
  3. Model 3: adjusted for model 2 plus end stage renal failure, history of heart failure or coronary artery disease, hyperthyroidism, malignancy, and chronic obstructive pulmonary disease
  4. BMI body mass index, CI confidence interval, F female, IFG impaired fasting glucose, M male, WC waist circumference