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Table 1 Baseline characteristics among 1414 patients with ACS

From: Genetic predisposition to type 2 diabetes is associated with severity of coronary artery disease in patients with acute coronary syndromes

Variables

Total

Single-vessel disease

Multi-vessel disease

P value

No. of patients

n = 1414

n = 490

n = 924

 

Demographics

 Age, median (IQR), years

60 (53–68)

58 (49–65)

61 (55–69)

< 0.001

 BMI, median (IQR), kg/m2

24.7 (22.7–26.9)

24.7 (22.5–26.8)

24.7 (22.9–27.0)

0.325

 Male, n (%)

1112 (78.6)

380 (77.5)

732 (79.2)

0.509

 Current smoking, n (%)

588 (41.6)

201 (41.0)

387 (41.9)

0.798

Diagnosis, n (%)

 NSTEMI

271 (19.2)

89 (18.2)

182 (19.7)

 

 STEMI

340 (24.0)

113 (23.1)

227 (24.6)

0.544

 UA

803 (56.8)

288 (58.8)

515 (55.7)

 

Medical history, n (%)

 Hypertension

753 (53.3)

219 (44.7)

534 (57.8)

< 0.001

 Type 2 diabetes

288 (20.4)

69 (14.1)

219 (23.7)

< 0.001

 Hypercholesterolemia

255 (18.0)

81 (16.5)

174 (18.8)

0.318

 Prior myocardial infarction

121 (8.6)

34 (7.0)

87 (9.4)

0.138

 Prior revascularization

112 (7.9)

32 (6.5)

80 (8.6)

0.192

 Stroke/transient ischemic arrack (TIA)

71 (5.0)

19 (3.9)

52 (5.6)

0.192

 Heart failure

12 (0.8)

2 (0.4)

10 (1.1)

0.236

 Chronic angina

168 (11.9)

43 (8.8)

125 (13.5)

0.011

 Chronic renal failure

8 (0.6)

3 (0.6)

5 (0.5)

1.000

 Chronic obstructive pulmonary diseases (COPD)/other chronic lung diseases (CLD)

8 (0.6)

4 (0.8)

4 (0.4)

0.459

 Peripheral vascular disease

11 (0.8)

2 (0.4)

9 (1.0)

0.348

Genetic information

 Family history of CAD, n (%)

117 (8.3)

36 (7.3)

81 (8.8)

0.412

 T2D-GRS, median (IQR)

48.5 (46.0–51.1)

48.1 (45.5–50.5)

48.7 (46.3–51.3)

< 0.001