Fig. 2

Representative serial CCTAs images. a A serial CCTAs of a non-diabetic patient. At the baseline CCTA (a1) (performed on April, 2014), no plaque was found on the proximal right coronary artery (pRCA). At the second CCTA (a2) (performed on July, 2018), a newly developed calcific plaque was noticed on the pRCA with minimal stenosis. b A serial CCTAs of a diabetic patient. At the baseline CCTA (b1) performed on February, 2013, a mixed plaque with mild stenosis was found on the proximal left anterior descending artery (pLAD). At the second CCTA (b2) performed on March, 2017, the mixed plaque on the pLAD has progressed into severe stenosis