Fig. 2

HHF events in EMPRISE and EMPA-REG OUTCOME. a The relative risk reduction of HHF in the first interim analysis of EMPRISE was consistent with that seen in EMPA-REG OUTCOME, confirming the robustness of empagliflozin’s HHF benefit in routine clinical practice, in a population with a broader CV risk profile, and against a DPP-4 inhibitor as an active comparator. b The first interim analysis of EMPRISE had a primary analysis of hospitalisation events with discharge diagnosis of HF in the primary position compared between empagliflozin and sitagliptin. However, secondary analyses showed that the HHF benefit with empagliflozin was robust even when using a broader definition of HHF (discharge diagnosis of HF in any position) or broadening the active comparator to include all DPP-4 inhibitors, not just sitagliptin. CV cardiovascular, DPP-4 dipeptidyl peptidase-4, HF heart failure, HHF hospitalisation for HF