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Table 2 Expression and statistical analysis results of microRNAs studied in T2DM

From: Significance of circulating microRNAs in diabetes mellitus type 2 and platelet reactivity: bioinformatic analysis and review

First author [reference] Expression of miRNA OR p value AUC
Sensitivity Specificity
Kong (2011) [29] ↑ miR-9
↑ miR-29a
↑ miR-30d
↑ miR34a
↑ miR-124a
↑ miR146a
↑ miR-375
  0.021
0.003
0.12
0.001
0.12
0.01
0.002
Karolina (2012) [30] ↑ miR-27a
↑ miR-320a
0.010
0.019
Zhang (2013) [31] ↓ miR-126 < 0.01
Liu (2014) [32] ↓ miR-126 3.5 < 0.05 0.792
Ghorbani (2017) [33] ↓ miR-21 0.01/0.03
Al-Muhtaresh (2018) [34] ↑ miR-375
↑ miR-9
1.12–1.151
0.972–1.006
0.001–0.05
0.33–0.954
0.78
0.532
Jiménez-Lucena (2018) [35] ↑ miR-30a-5p
↑ miR-150
↓ miR-103
↓ miR-28-3p
↓ miR-29a
↓ miR-9
< 0.001
< 0.001
< 0.001
< 0.001
< 0.001
< 0.001
Zampetaki (2010) [36] ↑ miR-28-3p
miR-24
miR-21
miR-20b
miR-15a
miR-126
miR-191
miR-197
miR-223
miR-320
miR-486
miR-150
miR-29b
Zhang (2015) [37] ↓ miR-126 0.967 0.0158 0.7778 0.6667
Balasubramanyam (2011) [44] ↓ miR-146a 0.015
Luo (2015) [45] ↓ miR-103b < 0.05
Olivieri (2015) [47] ↓ miR-126-3p
↓ miR-21-5p
0.032
< 0.001
Giannella (2017) [48] ↓ miR-126-3p 0.001, < 0.001
Witkowski [49] ↓ miR-126 0.226
Jansen [54] ↓ miR-126
↓ miR-26a
0.226
0.0094
Deng (2017) [55] ↓ miR-24 < 0.01 0.975  
Amr (2018) [56] ↓ miR-126
↑ miR-210
  < 0.01
< 0.01
0.96–0.98
0.95–0.98
Stępień (2018) [57] ↑ miR-193b-3p
↑ let-7i-5p
↑ miR-199a-3-5p
↑ miR-26b-5p
↑ miR-30b-5p
↑ miR-374a-5p
↑ miR-20a-3p
↑ miR-26a-5p
↑ miR-30c-5p
↓ miR-409-3p
↓ miR-95-3p
0.015
0.006
0.001
0.012
0.01
0.00001
0.064
0.075
0.055
0.004
0.041
Stratz (2014) [59] No significant differences in platelet miRNA profiles     
Fejes (2017) [60] ↓ miR-223
↓ miR-26b
↓ miR-126
↓ miR-140
< 0.01/0.382
< 0.01/0.011