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Table 1 Characteristics of microRNA studies in T2DM

From: Significance of circulating microRNAs in diabetes mellitus type 2 and platelet reactivity: bioinformatic analysis and review

First author (year of publication) [reference]

Studied miRNAs

Expression of miRNAs

T2DM/controls

Method

Mechanism

Kong (2011) [29]

miR-9

miR-29a

miR-30d

miR-34a

miR-124a

miR-146a

miR-375

↑ miR-9

↑ miR-29a

↑ miR-30d

↑ miR-34a

↑ miR-124a

↑ miR-146a

↑ miR-375

18/19

qRT-PCR

Glucose metabolism

Karolina (2012) [30]

miR-27a

miR-320a

↑ miR-27a

↑ miR-320a

50/46

microRNA profiling

And qRT-PCR

Glucose metabolism

Zhang (2013) [31]

miR-29b

miR-15a

miR-28-3p

miR-223

miR-126

↓ miR-126

30/30

qRT-PCR

Glucose metabolism

Liu (2014) [32]

miR-126

↓ miR-126

160/138

qRT-PCR

Glucose metabolism

Ghorbani (2017) [33]

miR-21

miR-126

miR-146a

↓ miR-21

45/42

qRT-PCR

Glucose metabolism

Al-Muhtaresh (2018) [34]

miR-375

miR-9

↑ miR-375

↑ miR-9

30/30

qRT-PCR

Glucose metabolism

Jiménez-Lucena (2018) [35]

miR-103

MiR-107

miR-126

miR-143

miR-144

miR-145

miR-150

miR-15a

miR-182

miR-192

miR-21

miR-223

miR-28-3p

miR-29a

miR-30a-5p

miR-30d

miR-320

miR-33a

miR-375

miR-657

miR-7

miR-9

miR-96

↑ miR-30a-5p

↑ miR-150

↓ miR-103

↓ miR-28-3p

↓ miR-29a

↓ miR-9

↓ miR-15a

↓ miR-126

↓ miR-145

↓ miR-375

↓ miR-223

107/355

qRT-PCR

Glucose metabolism

Zampetaki (2010) [36]

miR-24

miR-21

miR-20b

miR-15a

miR-126

miR-191

miR-197

miR-223

miR-320

miR-486

miR-150

miR-29b

miR-28-3p

↑ miR-28-3p

miR-24

miR-21

miR-20b

miR-15a

miR-126

miR-191

miR-197

miR-223

miR-320

miR-486

miR-150

miR-29b

80/80

microRNA profiling and qRT-PCR

miR-126: endothelial dysfunction

Zhang (2015) [37]

miR-126

↓ miR-126

20/20

qRT-PCR

Glucose metabolism

Balasubramanyam (2011) [44]

miR-146a

↓ miR-146a

20/20

qRT-PCR

Inflammation

Luo (2015) [45]

miR-103b

↓ miR-103b

79/46

qRT-PCR

Inflammation

Olivieri (2015) [47]

miR-126-3p

miR-21-5p

↓ miR-126-3p

↓ miR-21-5p

193/107

qRT-PCR

Inflammation

Giannella (2017) [48]

miR-126-3p

miR-126-5p

↓ miR-126-3p

68/53

qRT-PCR

Inflammation

Witkowski [49]

miR-126

↓ miR-126

46/-

QRT-PCR

Inflammation

Jansen (2016) [54]

miR-126

miR-222

miR-let7d

miR-21

miR-30

miR-92a

miR-139

miR-199a

MiR-26a

↓ miR-126

↓ miR-26a

55/80

qRT-PCR

Endothelial dysfunction

Deng (2017) [55]

miR-24

↓ miR-24

28/31

qRT-PCR

Endothelial dysfunction

Amr (2018) [56]

miR-126

MiR-210

↓ miR-126

↑ miR-210

100/20

qRT-PCR

miR-126: Endothelial dysfunction miR-2010: hypoxia

Stępień (2018) [57]

miR-126-3p

miR-126-5p

miR-193b-3p

miR-199a-3p

miR-20a-3p

miR-221-3p

miR-23b-3p

miR-26a-5p

miR-26b-5p

miR-29a-5p

MiR-30b-5p

miR-30c-5p

miR-374a-5p

miR-409-3p

miR-495-3p

miR-95-3p

let-7i-5p

↑ miR-193b-3p

↑ let-7i-5p

↑ miR-199a-3-5p

↑ miR-26b-5p

↑ miR-30b-5p

↑ miR-374a-5p

↑ miR-20a-3p

↑ miR-26a-5p

↑ miR-30c-5p

↓ miR-409-3p

↓ miR-95-3p

15/15

microRNA profiling and qRT-PCR

Angiogenesis

Stratz (2014) [59]

miR-377-5p

miR-628-3p

miR-3137

No significant differences in platelet miRNA profiles

30/30

microRNA profiling and qRT-PCR

Platelet reactivity

Fejes (2017) [60]

miR-223

miR-26b

miR-126

MiR-140

↓ miR-223

↓ miR-26b

↓ miR-126

↓ miR-140

28/23

qRT-PCR

Platelet reactivity