Skip to main content

Table 1 Characteristics of microRNA studies in T2DM

From: Significance of circulating microRNAs in diabetes mellitus type 2 and platelet reactivity: bioinformatic analysis and review

First author (year of publication) [reference] Studied miRNAs Expression of miRNAs T2DM/controls Method Mechanism
Kong (2011) [29] miR-9
miR-29a
miR-30d
miR-34a
miR-124a
miR-146a
miR-375
↑ miR-9
↑ miR-29a
↑ miR-30d
↑ miR-34a
↑ miR-124a
↑ miR-146a
↑ miR-375
18/19 qRT-PCR Glucose metabolism
Karolina (2012) [30] miR-27a
miR-320a
↑ miR-27a
↑ miR-320a
50/46 microRNA profiling
And qRT-PCR
Glucose metabolism
Zhang (2013) [31] miR-29b
miR-15a
miR-28-3p
miR-223
miR-126
↓ miR-126 30/30 qRT-PCR Glucose metabolism
Liu (2014) [32] miR-126 ↓ miR-126 160/138 qRT-PCR Glucose metabolism
Ghorbani (2017) [33] miR-21
miR-126
miR-146a
↓ miR-21 45/42 qRT-PCR Glucose metabolism
Al-Muhtaresh (2018) [34] miR-375
miR-9
↑ miR-375
↑ miR-9
30/30 qRT-PCR Glucose metabolism
Jiménez-Lucena (2018) [35] miR-103
MiR-107
miR-126
miR-143
miR-144
miR-145
miR-150
miR-15a
miR-182
miR-192
miR-21
miR-223
miR-28-3p
miR-29a
miR-30a-5p
miR-30d
miR-320
miR-33a
miR-375
miR-657
miR-7
miR-9
miR-96
↑ miR-30a-5p
↑ miR-150
↓ miR-103
↓ miR-28-3p
↓ miR-29a
↓ miR-9
↓ miR-15a
↓ miR-126
↓ miR-145
↓ miR-375
↓ miR-223
107/355 qRT-PCR Glucose metabolism
Zampetaki (2010) [36] miR-24
miR-21
miR-20b
miR-15a
miR-126
miR-191
miR-197
miR-223
miR-320
miR-486
miR-150
miR-29b
miR-28-3p
↑ miR-28-3p
miR-24
miR-21
miR-20b
miR-15a
miR-126
miR-191
miR-197
miR-223
miR-320
miR-486
miR-150
miR-29b
80/80 microRNA profiling and qRT-PCR miR-126: endothelial dysfunction
Zhang (2015) [37] miR-126 ↓ miR-126 20/20 qRT-PCR Glucose metabolism
Balasubramanyam (2011) [44] miR-146a ↓ miR-146a 20/20 qRT-PCR Inflammation
Luo (2015) [45] miR-103b ↓ miR-103b 79/46 qRT-PCR Inflammation
Olivieri (2015) [47] miR-126-3p
miR-21-5p
↓ miR-126-3p
↓ miR-21-5p
193/107 qRT-PCR Inflammation
Giannella (2017) [48] miR-126-3p
miR-126-5p
↓ miR-126-3p 68/53 qRT-PCR Inflammation
Witkowski [49] miR-126 ↓ miR-126 46/- QRT-PCR Inflammation
Jansen (2016) [54] miR-126
miR-222
miR-let7d
miR-21
miR-30
miR-92a
miR-139
miR-199a
MiR-26a
↓ miR-126
↓ miR-26a
55/80 qRT-PCR Endothelial dysfunction
Deng (2017) [55] miR-24 ↓ miR-24 28/31 qRT-PCR Endothelial dysfunction
Amr (2018) [56] miR-126
MiR-210
↓ miR-126
↑ miR-210
100/20 qRT-PCR miR-126: Endothelial dysfunction miR-2010: hypoxia
Stępień (2018) [57] miR-126-3p
miR-126-5p
miR-193b-3p
miR-199a-3p
miR-20a-3p
miR-221-3p
miR-23b-3p
miR-26a-5p
miR-26b-5p
miR-29a-5p
MiR-30b-5p
miR-30c-5p
miR-374a-5p
miR-409-3p
miR-495-3p
miR-95-3p
let-7i-5p
↑ miR-193b-3p
↑ let-7i-5p
↑ miR-199a-3-5p
↑ miR-26b-5p
↑ miR-30b-5p
↑ miR-374a-5p
↑ miR-20a-3p
↑ miR-26a-5p
↑ miR-30c-5p
↓ miR-409-3p
↓ miR-95-3p
15/15 microRNA profiling and qRT-PCR Angiogenesis
Stratz (2014) [59] miR-377-5p
miR-628-3p
miR-3137
No significant differences in platelet miRNA profiles 30/30 microRNA profiling and qRT-PCR Platelet reactivity
Fejes (2017) [60] miR-223
miR-26b
miR-126
MiR-140
↓ miR-223
↓ miR-26b
↓ miR-126
↓ miR-140
28/23 qRT-PCR Platelet reactivity