Fig. 7

Dapagliflozin prevented aortal sympathetic tone and stiffness in HFpEF pigs. TH expression in tissues from the LV and aorta was determined by immunofluorescence staining at the end of the study. Representative images are shown (a), TH-positive cells in the CSA of the LV and aorta and aortic stiffness index β were calculated (b). Values are expressed as the mean ± SD. n = 10 pigs per group. Statistical analyses were performed by one-way ANOVA followed by the Bonferroni post hoc test. ^*p < 0.05 vs. the Normal group, ^#p < 0.05 vs. the HEpEF group