Fig. 6

Effects of dapagliflozin on LV diastolic function and the compliance of HFpEF pigs. The functional status of the LV in HFpEF pigs with or without dapagliflozin treatment was assessed by echocardiography. E/A (a); E/e′ (b); DT (c): deceleration time; IVRT (d): isovolumetric relaxation time; EDPVR (e): end-diastolic pressure–volume relationship; LV-dp/dt (f): the rate of LV pressure decline in early diastole. Data are expressed as the mean ± SD. n = 10 pigs per group. Two-way repeated measures ANOVA was performed. ^*p < 0.05 vs. the Normal group, ^#p < 0.05 vs. the HFpEF group, ^&p < 0.05 vs. the 9th week of the same group